Trabectedin in the treatment of metastatic soft tissue sarcoma: cost-effectiveness, cost-utility and value of information.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
E J O SoiniT Joensuu

Abstract

to assess the cost-effectiveness of trabectedin compared with end-stage treatment (EST) after failure with anthracycline and/or ifosfamide in metastatic soft tissue sarcoma (mSTS). analysis was carried out using a probabilistic Markov model with trabectedin → EST and EST arms, three health states (stable disease, progressive disease and death) and a lifetime perspective (3% annual discount rate). Finnish resources (drugs, mSTS, adverse events and travelling) and costs (year 2008) were used. Efficacy was based on an indirect comparison of the STS-201 and European Organisation for Research and Treatment of Cancer trials. QLQ-C30 scale scores were mapped to 15D, Short Form 6D and EuroQol 5D utilities. The outcome measures were the cost-effectiveness acceptability frontier, incremental cost per life year gained (LYG) and quality-adjusted life year (QALY) gained and the expected value of perfect information (EVPI). trabectedin → EST was associated with 14.0 (95% confidence interval 9.1-19.2) months longer survival, €36 778 higher costs (€32 816 using hospital price for trabectedin) and €31 590 (€28 192) incremental cost per LYG with an EVPI of €3008 (€3188) compared with EST. With a threshold of €50 000 per LYG, trabectedin → EST ha...Continue Reading

Citations

Nov 7, 2013·Journal of Oncology Practice·Haitham W TuffahaPaul A Scuffham
Jun 22, 2016·Expert Opinion on Pharmacotherapy·Rita De SanctisArmando Santoro
May 9, 2012·International Journal of Technology Assessment in Health Care·Peivand Bastani, Aliasghar Ahmad Kiadaliri
Dec 20, 2011·Expert Opinion on Drug Metabolism & Toxicology·Angela Cioffi, Antoine Italiano
Apr 19, 2011·Clinical Medicine Insights. Oncology·Csaba Gajdos, Anthony Elias
Dec 8, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E J O SoiniT Nousiainen
Feb 25, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C BlomqvistM Tarkkanen

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BETA
surgical resection

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mSTS
Excel
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