Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study

Brazilian Oral Research
Marta Ferreira BastosP M Duarte

Abstract

Clinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim of this study was to evaluate bone healing and trabecular bone area (TBA) in spontaneously hypertensive rats (SHR), a well-established model of essential hypertension, when compared to normotensive rats (NTR). A critical-size defect was surgically created in the right tibia of SHR (n = 12) and normotensive rats (NTR; n = 12), while the contralateral tibia was left intact. Eight days later, the animals were sacrificed and the specimens processed in order to obtain decalcified sections. The area of newly-formed bone (NB) within the defect of the right tibia and the TBA in the left tibia were histometrically evaluated. At 8 days post-operative, SHR presented a significantly smaller area of NB when compared to NTR (p < 0.05). In addition, SHR demonstrated a lower TBA than NTR group. In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA.

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Citations

Aug 3, 2013·Aging Clinical and Experimental Research·Umberto TarantinoPietro Pistillo
May 11, 2012·Clinical and Experimental Hypertension : CHE·Janine Montenegro Toscano Moura de Medeiros VanderleiMario Taba
Feb 24, 2016·Journal of Endodontics·Christine Men MartinsLuciano Tavares Angelo Cintra
Jun 25, 2016·Nutrients·Sok Kuan WongSoelaiman Ima-Nirwana
Oct 14, 2016·Brazilian Oral Research·Christine Men MartinsJoão Eduardo Gomes-Filho
Jun 6, 2012·Journal of Applied Oral Science : Revista FOB·Natalia ManriqueCristina Antoniali
Jan 5, 2013·Implant Dentistry·Marta Ferreira BastosPoliana Mendes Duarte
Aug 25, 2019·Scientific Reports·Wacharaporn TiyasatkulkovitNarattaphol Charoenphandhu
Dec 1, 2020·International Journal of Implant Dentistry·Henning StaedtDiana Heimes
Jan 28, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Elvy Suhana Mohd RamliKok-Yong Chin

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