Trabecular bone formation in the healing of the rodent molar tooth extraction socket

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
H DevlinS Ayad

Abstract

The aim of this study was to investigate the nature of the template structure on which trabecular bone formation occurs during healing of the rodent tooth extraction socket, a well studied bone healing system. The presence of collagen type II mRNA has previously been described in the healing socket, although the formation of the protein or cartilage has not been observed. However, recent evidence from developmental and other bone healing studies indicates that collagen type III may be important in forming the preliminary scaffold on which bone trabeculae are formed. The maxillary right molar teeth were removed from rats under general anaesthesia and the animals killed at various times afterward. The tissues were examined using histological, in situ hybridization, and immunohistochemical staining techniques. It was concluded that collagen type IIA mRNA was produced by osteoblast cells of the socket, but that collagen type II, if present, would account for less than 0.01% of the total proteins extracted. During bone formation, Sharpey's fibers were seen radiating from the peripheral bone toward the center of the socket. These optically active collagen fibers were inserted into the forming bone trabeculae and were recognized by an...Continue Reading

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Citations

Aug 14, 2010·International Journal of Dentistry·Francisley Avila SouzaRoberta Okamoto
May 13, 2020·Journal of Periodontology·Franz Josef StraussReinhard Gruber
Jan 11, 2012·Clinical Oral Implants Research·Fabio VignolettiMariano Sanz
Dec 14, 1999·The American Journal of Pathology·K TingI Nishimura

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