Trabecular bone score as an assessment tool to identify the risk of osteoporosis in axial spondyloarthritis: a case-control study

Rheumatology
Kwi Young KangYeon Sik Hong

Abstract

To compare the trabecular bone score (TBS) between patients with axial spondyloarthritis (axSpA) and matched normal controls and identify risk factors associated with a low TBS. TBS and BMD were assessed in the two groups (axSpA and control) using DXA. Osteoporosis risk factors and inflammatory markers were also assessed. Disease activity and radiographic progression in the sacroiliac joint and spine were evaluated in the axSpA group. Multivariate linear regression analysis was performed to identify risk factors associated with TBS. In the axSpA group, 248 subjects were enrolled; an equal number of age- and sex-matched subjects comprised the control group. The mean TBS was 1.43 (0.08) and 1.38 (0.12) in the control and axSpA groups, respectively (P < 0.001); BMD at the lumbar spine did not differ between the two groups. The TBS was negatively correlated with ESR and CRP levels in the axSpA group only (P < 0.001 and P = 0.007, respectively). Syndesmophytes in the axSpA group was associated with lower TBS (P < 0.001) but higher lumbar BMD (P = 0.021) vs controls. In the multivariate analyses, ESR, CRP and spinal radiographic progression were significantly associated with TBS. TBS assessments revealed poor bone quality in patients...Continue Reading

References

Oct 1, 1992·Calcified Tissue International·T A LarnachT H Diamond
Feb 1, 1994·Annals of the Rheumatic Diseases·S DonnellyT D Spector
Feb 15, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy
Sep 21, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·U LangeK L Schmidt
Dec 9, 2008·Annals of the Rheumatic Diseases·D van der HeijdeUNKNOWN Assessment of SpondyloArthritis international Society (ASAS)
Aug 4, 2010·Current Rheumatology Reports·Marina Magrey, Muhammad Asim Khan
Mar 2, 2011·The American Journal of the Medical Sciences·Georg Schett
Oct 15, 2011·Arthritis Research & Therapy·Piet Geusens, Willem F Lems
Oct 2, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Barbara C SilvaJohn P Bilezikian
Jan 21, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Barbara C SilvaJohn P Bilezikian
Apr 2, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S KoltaC Roux
Sep 4, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F CosmanR Lindsay
Apr 3, 2015·Journal of Internal Medicine·M Lorentzon, S R Cummings
Apr 4, 2015·Annals of the Rheumatic Diseases·P MandlUNKNOWN European League Against Rheumatism (EULAR)
Jul 8, 2015·The British Journal of Radiology·A BazzocchiG Guglielmi
Oct 27, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eugene V McCloskeyJohn A Kanis
Jul 28, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Laura WildbergerBérengère Aubry-Rozier
Jan 24, 2017·Lancet·Joachim Sieper, Denis Poddubnyy
Feb 6, 2017·Autoimmunity Reviews·Ágnes SzentpéteryZoltán Szekanecz

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Citations

Dec 29, 2020·Frontiers in Medicine·Mie Jin Lim, Kwi Young Kang
Nov 27, 2020·Therapeutic Advances in Musculoskeletal Disease·Gavin Clunie, Nicole Horwood
Jun 16, 2021·Journal of Bone Metabolism·Sung Hye KongJung Hee Kim

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