Trabecular bone structures in the edentulous diastema of osteoporotic sheep

Journal of Dental Research
G DvorakR Haas

Abstract

The edentulous ovine diastema represents a suitable region for implantological research. Due to distinctive embryonic origin and mechanical loading, the edentulous diastema may respond differently to osteoporosis than tooth-bearing areas. To test this assumption, we subjected geriatric sheep to ovariectomy, calcium-/vitamin-D-restricted diet, and methylprednisolone administration. Adult control sheep remained untreated. Structural parameters and bone mineral density were determined by microcomputed tomography and conventional computed tomography, respectively. We report that the trabecular microstructure in the diastema was preserved from catabolic changes. In contrast, the premolar maxillary region of osteoporotic sheep had diminished trabecular bone mineral density, with the corresponding structural deteriorations. These results suggest that maxillary trabecular bone of the edentulous diastema does not respond to catabolic changes which occur in the tooth-bearing area in osteoporosis. Our findings imply that regional anatomic domains must be considered in the planning of pre-clinical studies, taking osteoporotic changes into account.

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Citations

Jun 4, 2013·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Yiqi XuYin Ding
Jul 23, 2011·Journal of Clinical Periodontology·Gabriella DvorakReinhard Gruber
Nov 23, 2010·Clinical Oral Implants Research·Gabriella DvorakReinhard Gruber
Oct 10, 2013·Clinical Oral Implants Research·Ralf OheimPia Pogoda

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