Abstract
This paper assesses interscan, interreader, and intrareader variability of C-arm CT and compares it to that of flat-panel volume-CT (fpVCT) and high-definition multi-detector-CT (HD-MDCT). Five cadaver knee specimens were imaged using C-arm-CT, fpVCT, and HD-MDCT. Apparent (app.) trabecular bone volume fraction (BV/TV), app. trabecular number (TbN), app. trabecular spacing (TbSp), and app. trabecular thickness (TbTh) of the proximal tibia were measured by three readers. Interreader, intrareader, and interscan variability for C-arm CT was expressed as coefficient of variation (CV), standard deviation (SD), and intraclass correlation coefficient (ICC). With the exception of app.TbSp (CV: 7.05-9.35%, SD: 0.06-0.09, ICC: 0.89-0.94), the variability of C-arm CT was low (CV: 2.41-6.43%, SD: 0.01-0.048, ICC: 0.65-0.98). Its interreader reliability (CV: 2.66-4.55%, SD: 0.01-0.03, ICC: 0.81-0.95) was comparable to that of HD-MDCT (CV: 2.41-4.08%, SD: 0.014-0.016, ICC: 0.95-0.96), and fpVCT (CV: 3.13-5.63%, SD: 0.009-0.036, ICC: 0.64-0.98) for all parameters except app.TbSp. C-arm CT is a reliable method for assessing trabecular bone architectural parameters with the exception of app.TbSp due to spatial resolution limitation.
References
May 1, 1988·Calcified Tissue International·A M Parfitt
Feb 1, 1997·Calcified Tissue International·X OuyangH K Genant
Feb 8, 2002·Clinical Biomechanics·B van RietbergenB MacDonald
May 28, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D C NewittS Majumdar
Aug 31, 2002·Radiology·Stephan G WetzelXiaonan Xue
Dec 5, 2002·Topics in Magnetic Resonance Imaging : TMRI·Felix W WehrliRichard Weening
Oct 1, 1956·Journal of Clinical Psychology·P HORST
Jun 8, 2004·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·W PistoiaP Rüegsegger
Jun 23, 2004·Bone·B R GombergA C Wright
Aug 2, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Charles H ChesnutLinda Mindeholm
Sep 15, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Maria BenitoPeter J Snyder
Sep 15, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Masako ItoHajime Orimo
Sep 29, 2005·The Journal of Clinical Endocrinology and Metabolism·Stephanie BoutroyPierre D Delmas
Jan 18, 2006·Statistics in Medicine·Shiquan RenShenghan Lai
Mar 11, 2006·European Radiology·Rajiv GuptaThomas Flohr
Apr 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Martin StauberRalph Müller
Nov 9, 2006·Medical Physics·M J DalyJ C Irish
Dec 22, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth Sornay-RenduPierre D Delmas
May 24, 2007·Acta Radiologica·Z F ShengE Y Liao
Jun 2, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Joseph MeltonSundeep Khosla
Jun 26, 2007·European Radiology·Willi A Kalender, Yiannis Kyriakou
Aug 8, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Joseph MeltonSundeep Khosla
Apr 16, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·X Henry ZhangX Edward Guo
Apr 16, 2008·Journal of Anatomy·Volker BraunsteinStefan Milz
Apr 30, 2008·Skeletal Radiology·Benjamin ReichardtRajiv Gupta
Oct 16, 2008·Calcified Tissue International·Gerd DiederichsAhi Issever
Oct 23, 2008·AJR. American Journal of Roentgenology·Akio HiwatashiHiroshi Honda
Nov 13, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Rajiv GuptaThomas J Brady
Nov 18, 2008·Radiology·Miriam A BredellaRajiv Gupta
Dec 5, 2008·Acta Radiologica·S P LiuR C Dai
Jan 6, 2009·Cardiovascular and Interventional Radiology·Alda TamMichael J Wallace
Apr 3, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ahi S IsseverGerd Diederichs
Apr 21, 2009·Journal of Neurosurgery·Alim P MithaRajiv Gupta
May 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christian GraeffPhilippe K Zysset
May 12, 2009·Skeletal Radiology·Arnold C CheungRajiv Gupta
May 16, 2009·Bone·Gerd DiederichsAhi S Issever
Aug 1, 2009·AJNR. American Journal of Neuroradiology·A HiwatashiH Honda
Feb 9, 2010·Spine·Alda L TamMichael J Wallace
Citations
Aug 29, 2012·Skeletal Radiology·Roman GuggenbergerGustav Andreisek
Mar 30, 2013·Investigative Radiology·Roman GuggenbergerHatem Alkadhi
Nov 8, 2011·Bone·Lars MulderKeita Ito
Dec 17, 2014·BoneKEy Reports·Torsten LowitzKlaus Engelke
May 4, 2013·The British Journal of Radiology·C M PhanR Gupta
Mar 24, 2016·European Radiology·H LangE Kotter
Jun 14, 2012·IEEE Transactions on Bio-medical Engineering·P ZerfassK Engelke
Feb 27, 2015·European Radiology·Amit MehndirattaRajiv Gupta
Nov 28, 2013·European Journal of Radiology·Jan S BauerChristoph W Raeth
Apr 11, 2012·Investigative Radiology·Roman GuggenbergerGustav Andreisek
Aug 7, 2017·Skeletal Radiology·Manoj MannilRoman Guggenberger
Feb 24, 2011·Clinical Orthopaedics and Related Research·Andrew J BurghardtSharmila Majumdar
Nov 24, 2016·PloS One·Oliver BissingerAndreas Kolk
Jan 1, 2014·Journal of Medical Engineering·T LowitzK Engelke