PMID: 8970867Jan 1, 1995Paper

Trabeculectomy with mitomycin C: an electron microscopic and clinical study

International Ophthalmology
M E TuraçliH Sencer

Abstract

A prospective and randomized clinical trial was conducted to investigate the pressure-lowering effect of mitomycin C-aided trabeculectomy in the Turkish population. The scleral tissues excised during the operation were examined by light and electron microscopy. The study population consisted of 26 patients undergoing mitomycin C-aided trabeculectomy and another 26 patients subjected to trabeculectomy without mitomycin C serving as controls. The treatment groups consisted of primary open-angle and closed-angle glaucomas, congenital glaucomas, various types of secondary glaucomas and prior failed trabeculectomies. The decrease in IOP was more marked (P < 0.01) and the number of additional medications needed post-operatively was less in the mitomycin C group (P < 0.01). There were no serious complications except for transient hypotony in one mitomycin-treated eye. Transmission electron microscopic examinations showed differences between the control and mitomycin applied trabecular blocks. At the scleral dissection plane where mitomycin was applied, collagen fibrils were frayed with a loss of proteoglycan cross-links. Fibroblasts demonstrated pyknotic nuclei and loss of cell processes. In the control group, active fibroblasts and r...Continue Reading

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Citations

Jan 16, 2018·Journal of Glaucoma·Pierre G MardelliZeina Bakkour
Jun 5, 2003·Acta Ophthalmologica Scandinavica·Cengiz AkarsuBerati Hasanreisoglu

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