Trace administration of vitamin E can retrieve and prevent UV-irradiation- and metal exposure-induced memory deficits in nematode Caenorhabditis elegans

Neurobiology of Learning and Memory
Huayue YeDayong Wang

Abstract

Vitamin E (alpha-tocopherol), a lipid-soluble anti-oxidant, prevents the uncontrolled propagation of lipid peroxidation by free radicals. Nevertheless, there is weak or no evidence of a protective effect of previous vitamin E intake on cognitive function in humans. In the present study, we explored the thermosensation model to investigate the possible effects of vitamin E administration on memory behaviors in Caenorhabditis elegans. Administration of 100 and 200microg/mL of vitamin E had no significant effects on the memory for different time intervals, whereas relatively high concentration (400microg/mL) of vitamin E exposure shortened the extinction period of the association paradigm (food at 20 degrees C). Following the UV-irradiation, post-treatment with 200microg/mL of vitamin E not only retrieved the UV-irradiation-induced memory deficits, but also enhanced the memory functions in UV-irradiating animals. Post-treatment with trace vitamin E could also ameliorate the memory deficits in metal (Al or Pb) exposed worms. In addition, pre-treatment with 200microg/mL of vitamin E could effectively prevent the occurrence of memory deficits induced by metal exposure and UV-irradiation. Therefore, the close association may exist bet...Continue Reading

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Citations

Jan 2, 2010·Archives of Environmental Contamination and Toxicology·Yanfen ZhangDayong Wang
Aug 1, 2013·Journal of Photochemistry and Photobiology. B, Biology·Rui MorgadoSusana Loureiro
Dec 18, 2008·Neurotoxicology and Teratology·Kirsten J HelmckeMichael Aschner
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Jul 4, 2009·Ecotoxicology and Environmental Safety·Xiaojuan XingDayong Wang
Jul 1, 2009·Environmental Toxicology and Pharmacology·Xiaojuan XingDayong Wang
May 1, 2009·Environmental Toxicology and Pharmacology·Min Du, Dayong Wang
May 5, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Wen-Han WangChao-Jun Li
Jun 5, 2013·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Asuka NishinoTetsuya Matsuura
Mar 12, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Asuka NishinoTetsuya Matsuura
Jul 31, 2014·Metallomics : Integrated Biometal Science·Chan-Wei Yu, Vivian Hsiu-Chuan Liao

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