Trace Amine-Associated Receptor 1 Regulation of Methamphetamine Intake and Related Traits

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
John H HarknessTamara J Phillips

Abstract

Continued methamphetamine (MA) use is dependent on a positive MA experience and is likely attenuated by sensitivity to the aversive effects of MA. Bidirectional selective breeding of mice for high (MAHDR) or low (MALDR) voluntary consumption of MA demonstrates a genetic influence on MA intake. Quantitative trait locus (QTL) mapping identified a QTL on mouse chromosome 10 that accounts for greater than 50% of the genetically-determined differences in MA intake in the MAHDR and MALDR lines. The trace amine-associated receptor 1 gene (Taar1) is within the confidence interval of the QTL and encodes a receptor (TAAR1) that modulates monoamine neurotransmission and at which MA serves as an agonist. We demonstrate the existence of a non-functional allele of Taar1 in the DBA/2J mouse strain, one of the founder strains of the selected lines, and show that this non-functional allele co-segregates with high MA drinking and with reduced sensitivity to MA-induced conditioned taste aversion (CTA) and hypothermia. The functional Taar1 allele, derived from the other founder strain, C57BL/6J, segregates with low MA drinking and heightened sensitivity to MA-induced CTA and hypothermia. A role for TAAR1 in these phenotypes is corroborated in Taar...Continue Reading

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Citations

Nov 3, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antonio FerragudPietro Cottone
Nov 12, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Emily C EastwoodTamara J Phillips
Oct 31, 2018·Genes, Brain, and Behavior·Shkelzen ShabaniTamara J Phillips
Jun 27, 2018·Pharmacological Reviews·Raul R GainetdinovMark D Berry
May 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qiu T RuanCamron D Bryant
May 20, 2020·Genes, Brain, and Behavior·Cheryl ReedTamara J Phillips
Jan 8, 2016·The European Journal of Neuroscience·Kevin D LominacKaren K Szumlinski
Apr 24, 2018·Frontiers in Pharmacology·Ilya SukhanovRaul R Gainetdinov
Oct 7, 2015·Frontiers in Neuroscience·Tamara J Phillips, Shkelzen Shabani
Mar 15, 2018·Frontiers in Pharmacology·Catherine F MoorePietro Cottone
Apr 11, 2018·Frontiers in Pharmacology·Jian-Feng Liu, Jun-Xu Li
Jul 20, 2019·The Journal of Pharmacology and Experimental Therapeutics·Nicholas B MinerAaron Janowsky
Oct 3, 2015·Alcoholism, Clinical and Experimental Research·Angela R OzburnJohn C Crabbe
Jan 23, 2016·The Journal of Pharmacology and Experimental Therapeutics·Linda D SimmlerMatthias E Liechti
Nov 18, 2016·Frontiers in Neuroscience·Shkelzen ShabaniTamara J Phillips
Jan 25, 2020·Cellular and Molecular Neurobiology·Jianfeng LiuJun-Xu Li
May 26, 2018·Expert Opinion on Therapeutic Targets·Michael D SchwartzRaul R Gainetdinov
Oct 27, 2018·Neuropharmacology·Ilya SukhanovAnton Yu Bespalov
Oct 9, 2020·Neuroscience and Biobehavioral Reviews·Seetal DoddMichael Berk
Feb 6, 2021·International Journal of Molecular Sciences·Elissa K FultzKaren K Szumlinski
Sep 14, 2021·Frontiers in Psychiatry·Tamara J PhillipsElissa J Chesler

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