Trace Amine-Associated Receptors as Novel Therapeutic Targets for Immunomodulatory Disorders

Frontiers in Pharmacology
Sherri L Christian, Mark D Berry

Abstract

Trace amines and their receptors (trace amine-associated receptors; TAARs) are an emerging pharmacological target for the treatment of human disorders. While most studies have focused on their therapeutic potential for neurologic and psychiatric disorders, TAARs are also expressed throughout the periphery, including prominent expression in human leukocytes. Furthermore, recent independent, unbiased metabolomic studies have consistently identified one or more TAAR ligands as potential etiologic factors in inflammatory bowel disease (IBD). The putative role of TAARs in diseases such as IBD that are associated with hyperactive immune responses has not, however, previously been systematically addressed. Here, we review the current state of the knowledge of the effects of TAARs on leukocyte function, in particular in the context of mucosal epithelial cells that interface with the environment; developing a model whereby TAARs may be considered as a novel therapeutic target for disorders associated with dysregulated immune responses to environmental factors. In this model, we hypothesize that altered trace amine homeostasis results in hyperactivity of the immune system. Such loss of homeostasis can occur through many different mechani...Continue Reading

References

Sep 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J M Lauweryns, L Van Ranst
Jan 1, 1993·Fundamental & Clinical Pharmacology·M A Vieira-Coelho, P Soares-da-Silva
May 1, 1993·The Anatomical Record·R I LinnoilaK L Becker
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·B BorowskyC Gerald
Oct 16, 2003·Genomics·William B VantiBrian F O'Dowd
May 18, 2004·Nature Medicine·Thomas S ScanlanDavid K Grandy
Jul 5, 2005·Schizophrenia Research·Mike Bly
Feb 7, 2006·Journal of Proteome Research·Claire L Gavaghan McKeeJeremy K Nicholson
Aug 1, 2006·Nature·Stephen D Liberles, Linda B Buck
Sep 16, 2006·Digestive Diseases and Sciences·F MagroP Soares-da-Silva
Jan 30, 2007·BMC Medical Genetics·Makiko ShimizuHiroshi Yamazaki
Feb 3, 2007·Journal of Proteome Research·Julian R MarchesiYulan Wang
Feb 8, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Grazia ChielliniRiccardo Zucchi
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel N FrankNorman R Pace
Sep 29, 2007·Journal of Neuroimmunology·Daniel A NelsonKenneth L Bost
Dec 18, 2007·The Journal of Pharmacology and Experimental Therapeutics·Lothar LindemannMarius C Hoener
Jun 17, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mark KiddRoswitha Pfragner
Jun 28, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·Chi-Un PaeAlessandro Serretti
Nov 6, 2008·Cell·Jean B RegardShaun R Coughlin
Feb 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ashiq HussainSigrun I Korsching
Jun 6, 2009·The European Journal of Neuroscience·S GliemI Manzini
Jul 29, 2009·PloS One·Janet JanssonPhilippe Schmitt-Kopplin
Nov 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Amyaouch BradaiaBernhard Bettler
Dec 17, 2009·Journal of Psychiatric Research·Daniel J MüllerJames L Kennedy
Feb 20, 2010·BMC Evolutionary Biology·Eric J VallenderGregory M Miller
Mar 17, 2010·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S C Mitchell, R L Smith
May 25, 2010·Psychiatry Research·Chi-Un PaeAlessandro Serretti
Oct 27, 2010·PloS One·Tatyana D SotnikovaRaul R Gainetdinov
Nov 26, 2010·Applied and Environmental Microbiology·Pilar Fernández de PalenciaPaloma López
Jun 15, 2011·Molecular Pharmacology·Stefano EspinozaRaul R Gainetdinov
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·David M FerreroStephen D Liberles
Dec 30, 2011·Inflammopharmacology·Saskia Thomas, Daniel C Baumgart

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Citations

Mar 23, 2019·International Journal of Molecular Sciences·Antonella Di PizioDietmar Krautwurst
Sep 29, 2020·Journal of Biomedical Science·Lesha Pretorius, Carine Smith
Aug 3, 2019·The Journal of Pharmacology and Experimental Therapeutics·Nina DedicKenneth S Koblan
Dec 15, 2019·Cellular and Molecular Neurobiology·Katlynn Bugda GwiltGregory M Miller
Dec 12, 2018·Genes, Brain, and Behavior·Seong-Il Eyun
Jan 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Esmé Jansen van VurenBrian H Harvey
Nov 19, 2020·International Journal of Molecular Sciences·Pinelopi I ArtemakiChristos K Kontos

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Methods Mentioned

BETA
pharmacotherapy
biopsies

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