Abstract
Methyl mercury (MeHg) has been shown to change Coxsackie virus type B3 (CB3) myocarditis in a direction compatible with the development of chronic disease. Murine models of CB3 myocarditis closely mimic the pathogenesis in humans. There are also indications that metals, such as mercury, and trace elements may interact and adversely affect viral replication and development of inflammatory lesions. The effects of low-dose MeHg exposure on myocardial trace element distribution, as determined by means of nuclear microscopy, was studied in CB3 myocarditis. Balb/c mice were fed a MeHg-containing diet (3.9 mg/kg diet) for 12 wk prior to infection. Areas of inflammatory lesions in the myocardium were identified by traditional histologic examination, and serial tissue sections in these selected areas were used for immune histology (macrophages), in situ hybridization of virus genomes, and nuclear microscopy of tissue trace element distribution. Areas with no inflammation or virus were compared with areas of ongoing inflammation and viral replication. In the inflammatory lesions of MeHg-exposed mice as compared to nonexposed mice, the myocardial contents of calcium (Ca), manganese (Mn), and iron (Fe) were significantly increased, whereas...Continue Reading
Citations
Oct 23, 2010·Archives of Toxicology·Douglas B Kell
Feb 16, 2002·The Science of the Total Environment·Eva FunsethNils-Gunnar Ilbäck
Jun 15, 2007·Critical Reviews in Food Science and Nutrition·Nils-Gunnar Ilbäck, Göran Friman
Oct 11, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jennifer F NylandEllen K Silbergeld
Feb 27, 2003·Pancreas·Nils-Gunnar IlbäckGöran Friman
Aug 28, 2009·Trends in Immunology·Michael Schiraldi, Marc Monestier
Apr 29, 2009·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Christina Nyström-RosanderNils-Gunnar Ilbäck
Sep 4, 2008·Journal of Pharmacological and Toxicological Methods·Nils-Gunnar IlbäckGöran Friman
Jun 21, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Nils-Gunnar IlbäckGöran Friman
Feb 24, 2007·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Peter FriskNils-Gunnar Ilbäck
Aug 4, 2007·Congestive Heart Failure·Leslie T CooperNicholas V C Ralston
Apr 6, 2005·Toxicology and Applied Pharmacology·S HavarinasabP Hultman
Jan 25, 2005·Toxicology·Bo HäggqvistPer Hultman
May 19, 2004·Toxicology·Nils-Gunnar IlbäckUlf Lindh
Jun 6, 2015·Biological Trace Element Research·Guangtao XuXiaojun Yu
Apr 18, 2006·Environmental Research·N-G IlbäckF Watt
Sep 25, 2007·Environmental Research·Peter FriskNils-Gunnar Ilbäck
Feb 22, 2005·Environmental Research·Alan H Stern
Mar 23, 2015·Current Treatment Options in Cardiovascular Medicine·Antonio L Perez, W H Wilson Tang
May 4, 2004·Environmental Health Perspectives·John H Weisburger
May 4, 2004·Environmental Health Perspectives·Steven Earl Salmony
May 4, 2004·Environmental Health Perspectives·Deborah Schoen
May 4, 2004·Environmental Health Perspectives·Lorenzo Tomatis
May 4, 2004·Environmental Health Perspectives·Ellen K Silbergeld
May 4, 2004·Environmental Health Perspectives·Jennifer B Sass, Herbert L Needleman
Oct 31, 2009·Basic & Clinical Pharmacology & Toxicology·Juliana ValentiniFernando Barbosa
Apr 15, 2004·Nutrition Reviews·Hing Man Chan, Grace M Egeland