Trace elements and antioxidant enzymes associated with oxidative stress in the pre-eclamptic/eclamptic mothers during fetal circulation

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Reena NegiHari D Khanna

Abstract

Pre-eclampsia is associated with oxidative stress in the maternal circulation. The aim of the study was to access the oxidative stress status by quantification of byproducts generated during lipid peroxidation; deficient antioxidant activity and inadequate trace elements during oxidative damage in the umbilical cord blood of pre-eclamptic/eclamptic mothers and its effect on the fetal outcome. In a case control study umbilical cord blood samples were collected during delivery from cases of pre-eclamptic/eclamptic mothers and from normotensive (uncomplicated pregnancy) subjects as controls. Concentrations of malondialdehyde, trace elements (Zn, Cu, Se, Mg) and antioxidant enzymes (SOD, GPx) were determined. Decreased levels of Zinc (p < 0.001), Copper (p < 0.001), Selenium (p < 0.005), Magnesium (p < 0.05), Superoxide dismutase (p < 0.001), Glutathione Peroxidase (p < 0.001) and elevated levels of malondialdehyde (marker of lipid peroxidation) in the umbilical cord blood of pre-eclamptic and eclamptic pregnancies were observed. Positive correlation between Zn and SOD (Pearson r = 0.581, p < 0.001), Cu and SOD (Pearson r = 0.576, p < 0.001) and Se and GPx (Pearson r = 0.445, p < 0.005) was also observed. The reduced levels of trac...Continue Reading

References

Mar 29, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Makino
Dec 30, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·S K Jain
Apr 13, 2001·JAMA : the Journal of the American Medical Association·J C ChambersJ S Kooner
Sep 4, 2001·The Journal of Maternal-fetal Medicine·B AdamC Talu
Aug 27, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Carolina M Maier, Pak H Chan
Jul 22, 2005·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Laura A Stokowski
Oct 15, 2008·Hypertension·Hiten D MistryFiona Broughton Pipkin
Sep 8, 2010·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Azam MalekiSaeideh Mazloomzadeh
Dec 1, 2010·The Journal of Obstetrics and Gynaecology Research·Neerja RaniRani Kumar

❮ Previous
Next ❯

Citations

Jul 24, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Vania B RezendeValeria C Sandrim
Jan 29, 2016·Clinical and Experimental Hypertension : CHE·Vandita D'SouzaSadhana Joshi
May 15, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Perihan OzturkArzu Ataseven
Oct 10, 2015·Biological Trace Element Research·Maryam SahebariMajid Ghayour-Mobarhan
Apr 6, 2016·Environmental Health : a Global Access Science Source·Jean-Pierre Elongi MoyeneBenoit Nemery
Sep 9, 2015·Journal of Translational Medicine·Lorena BermúdezEmpar Lurbe
Aug 19, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Murat BakacakGürkan Kıran
Sep 23, 2014·International Journal of Hygiene and Environmental Health·Iman Al-SalehAbdullah Rabbah
Aug 20, 2015·International Journal of Preventive Medicine·Zatollah Asemi, Ahmad Esmaillzadeh
Oct 31, 2015·Biological Trace Element Research·Min XuShuyan Lv
Aug 10, 2016·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Alane Cabral Menezes de OliveiraRaphaela Costa Ferreira
Nov 12, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Alíssia Cardoso da SilvaJosé Geraldo Lopes Ramos
Dec 3, 2016·PloS One·Abdelmageed ElmugabilGasim I Gasim
Feb 9, 2017·Clinical Nutrition Research·Mahdiyeh SheikhiZamzam Paknahad
Dec 18, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Sarah A MarshallEuan M Wallace
Aug 11, 2017·Environmental Science and Pollution Research International·Samia AzabouMoncef Nasri
Jan 8, 2021·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Aditi A GodhamgaonkarSadhana R Joshi
May 29, 2021·Current Medical Science·Yi TangYuan-Yuan Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.