Trace fear conditioning is reduced in the aging rat

Neurobiology of Learning and Memory
Matthew D McEchronMarieke R Gilmartin

Abstract

Auditory trace fear conditioning is a hippocampus-dependent learning task that requires animals to associate an auditory conditioned stimulus (CS) and a fear-producing shock-unconditioned stimulus (US) that are separated by an empty 20-s trace interval. Previous studies have shown that aging impairs learning performance on hippocampus-dependent tasks. This study measured heart rate (HR) and freezing fear responses to determine if aging impairs hippocampus-dependent auditory trace fear conditioning in freely moving rats. Aging and Young rats received one long-trace fear conditioning session (10 trials). Each trial consisted of a tone-CS (5 s) and a shock-US separated by an empty 20-s trace interval. The next day rats received CS-alone retention trials. Young rats showed significantly larger HR and freezing responses on the initial CS-alone retention trials compared to the Aging rats. A control group of aging rats received fear conditioning trials with a short 1-s trace interval separating the CS and US. The Aging Short-Trace Group showed HR and freezing responses on the initial CS alone retention trials that were similar to the Young Long-Trace Group, but greater than the Aging Long-Trace Group. A second aging control group rece...Continue Reading

Citations

Jan 20, 2006·Behavioral Neuroscience·Bernard G SchreursCarrie A Smith-Bell
Jun 14, 2006·Behavioral Neuroscience·James R Moyer, Thomas H Brown
Nov 19, 2011·Experimental Aging Research·Matthew J Sanders
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Jun 28, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marieke R GilmartinKamran Diba
Jun 27, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marco PetersTim Tully
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