Tracer coupling among regenerated amacrine cells in the retina of the goldfish

Visual Neuroscience
Peter Hitchcock

Abstract

This study sought to characterize the tracer coupling of regenerated amacrine cells in the retina of the goldfish and assess the integration of regenerated neurons into existing retinal circuits. Regeneration of new neurons from injury-induced progenitors was stimulated by surgically excising a small rectangular piece of retina. Several months after regeneration was complete, intracellular injections of Neurobiotin, a gap junction-permeant tracer, were made into single regenerated amacrine cells or nonregenerated (extant) amacrine cells lying outside the regenerated patch. Two groups of amacrine cells were injected: those that in normal retina are tracer coupled and a single type (the radiate amacrine cell) that is not. The data show that regenerated amacrine cells are tracer coupled to each other and to their homologous counterparts outside the patch of regenerated retina. Regenerated radiate cells possess morphologically abnormal dendrites, but these processes can extend out of regenerated retina into surrounding normal retina. Similarly, the dendrites of extant radiate cells, severed by the original lesion, can regenerate into the patch of regenerated retina. These results indicate that in the goldfish retina the cell-specif...Continue Reading

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Citations

Jan 15, 2010·Journal of Ocular Biology, Diseases, and Informatics·Sonya E L CraigPeter F Hitchcock
Jan 15, 2014·Progress in Retinal and Eye Research·Jenny R Lenkowski, Pamela A Raymond
Jan 28, 2014·British Journal of Pharmacology·E GramageP Hitchcock
Apr 20, 2004·Progress in Retinal and Eye Research·Peter HitchcockDeborah Otteson
Jan 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Katia Del Rio-Tsonis, Panagiotis A Tsonis
Feb 15, 2017·Stem Cells International·Krista M BeachDeborah C Otteson

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