PMID: 9524106Apr 2, 1998Paper

Tracer transport and metabolism in a patient with juvenile pilocytic astrocytoma. A PET study

Journal of Neuro-oncology
U RoelckeK L Leenders

Abstract

We studied a patient with juvenile pilocytic astrocytoma (JPA) using positron emission tomography (PET), 18F-fluorodeoxyglucose (FDG), 11C-methionine (MET), and 82Rubidium (RUB). Non-linear fitting and multiple time graphical plotting of the dynamic PET data revealed values for tumor plasma volume, blood-brain barrier transport rate constants and tracer distribution volume in the range of glioblastomas and meningiomas, or higher. Likewise, the steady-state accumulation of MET and FDG was increased. With regard to the known vascular composition of JPA, our data suggest that increased transport and distribution considerably contribute to the high net tracer uptake observed in this tumor.

Citations

Apr 25, 2012·Journal of Neuro-oncology·Tatsuki AkiToru Iwama
Sep 24, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Csaba Juhász, Edit Bosnyák
Mar 29, 2019·Nuclear Medicine Communications·Amir H KhandaniMarijana Ivanovic

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