Tracer uptake in mediastinal and paraaortal thoracic lymph nodes as a potential pitfall in image interpretation of PSMA ligand PET/CT

European Journal of Nuclear Medicine and Molecular Imaging
Ali Afshar-OromiehUwe Haberkorn

Abstract

Since the introduction of 68Ga-PSMA-11 PET/CT for imaging prostate cancer (PC) we have frequently observed mediastinal lymph nodes (LN) showing tracer uptake despite being classified as benign. The aim of this evaluation was to further analyze such LN. Two patient groups with biphasic 68Ga-PSMA-11 PET/CT at 1 h and 3 h p.i. were included in this retrospective evaluation. Group A (n = 38) included patients without LN metastases, and group B (n = 43) patients with LN metastases of PC. SUV of mediastinal/paraaortal LN of group A (n = 100) were compared to SUV of LN metastases of group B (n = 91). Additionally, 22 randomly selected mediastinal and paraaortal LN of patients without PC were immunohistochemically (IHC) analyzed for PSMA expression. In group A, 7/38 patients (18.4%) presented with at least one PSMA-positive mediastinal LN at 1 h p.i. and 3/38 (7.9%) positive LN at 3 h p.i. with a SUVmax of 2.3 ± 0.7 at 1 h p.i. (2.0 ± 0.7 at 3 h p.i.). A total of 11 PSMA-positive mediastinal/paraaortal LN were detected in nine patients considering both imaging timing points. SUVmax of LN-metastases was 12.5 ± 13.2 at 1 h p.i. (15.8 ± 17.0 at 3 h p.i.). SUVmax increased clearly (> 10%) between 1 h and 3 h p.i. in 76.9% of the LN metasta...Continue Reading

References

Sep 28, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 1, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Christian M ZechmannUwe Haberkorn
Sep 25, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Thomas KrohnFlorian F Behrendt
Nov 21, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn
Mar 21, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias EiberMarkus Schwaiger
Apr 18, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ken HerrmannMichael Lassmann
Aug 22, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ali Afshar-OromiehUwe Haberkorn
Nov 14, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Carsten-Oliver SahlmannSameh Hijazi
Jun 5, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn
Jan 8, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ali Afshar-OromiehUwe Haberkorn
Mar 11, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehClemens Kratochwil
Apr 30, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Maurits WondergemIgle J de Jong
May 13, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn
Aug 3, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Sara SheikhbahaeiSteven P Rowe

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Citations

Jun 6, 2018·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Bettina Beuthien-Baumann, Stefan A Koerber
Oct 20, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Ian AlbertsAli Afshar-Oromieh
Dec 23, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Ian AlbertsAli Afshar-Oromieh
Dec 10, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Yu ZhaoKuangyu Shi
Dec 4, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Ian AlbertsAli Afshar-Oromieh
Aug 25, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bernhard GrubmüllerMarkus Hartenbach
May 21, 2019·Nuclear Medicine Communications·Burak SönmezerGamze Capa Kaya
Jan 23, 2021·Nuclear Medicine Communications·Clemens MingelsIan Alberts
Apr 19, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Le Wen ChiuRobert R Flavell
Jun 1, 2021·PET Clinics·Ian L AlbertsAli Afshar-Oromieh
Feb 7, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ian AlbertsAli Afshar-Oromieh

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