Tracheal allograft transplantation in rats: the role of different immunosuppressants on preservation of respiratory epithelium

Transplantation Proceedings
S SchrepferH Reichenspurner

Abstract

Bronchiolitis obliterans is the most significant complication adversely affecting the survival of lung allograft recipients. Injury and loss of epithelium are associated with obliteration of the airway lumen. The aim of this study was to examine the effects of various immunosuppressants on airway epithelium. Tracheae from Brown Norway donors were heterotopically transplanted into the greater omentum of Lewis (allografts) or Brown Norway (isografts) animals. Recipients were treated for 28 days with FK778 (20 mg/kg), tacrolimus (4 mg/kg), or sirolimus (2 mg/kg). Tracheal segments were evaluated for the degree of luminal occlusion as well as the type and percent of luminal epithelial cell coverage. All agents inhibited peritracheal infiltration and luminal obliteration. Tacrolimus- more than sirolimus-treated recipients showed partial preservation of the luminal epithelial coverage, whereas animals that received FK778 showed no respiratory epithelium. The epithelial loss was accompanied by the appearance of fibrous tissue, which replaced the mucosa. Tacrolimus as well as sirolimus effectively prevented the development of obliterative airway disease whereas tacrolimus and, to a lesser degree, sirolimus preserved epithelial cells as...Continue Reading

References

May 26, 1998·Scandinavian Journal of Immunology·C G PerssonC Svensson
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A DosanjhR E Morris

❮ Previous
Next ❯

Citations

Mar 17, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Xiaofei LiKun Liu
Dec 30, 2009·The Journal of Thoracic and Cardiovascular Surgery·Jinbo ZhaoXiaofei Li
Oct 19, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Julien GuihaireSonja Schrepfer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Louise L SouthwoodC Wayne McIlwraith
American Journal of Respiratory Cell and Molecular Biology
Eric M GendenLloyd Mayer
The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
J HardwickeD Thomas
© 2022 Meta ULC. All rights reserved