PMID: 8956756Dec 1, 1996Paper

Tracheal autograft prefabrication using microfibrillar collagen and bone morphogenetic protein

Archives of Otolaryngology--head & Neck Surgery
D B Kuriloff, J N Fayad

Abstract

To investigate the feasibility of prefabricating a tracheal autograft capable of microvascular free tissue transfer using microfibrillar collagen (Avitene) as a carrier for bone morphogenetic protein (BMP). Using heterotopic bone induction and soft tissue molding, an attempt was made to prefabricate a homologous tracheal autograft in a rodent free flap model. In 12 male Sprague-Dawley rats, linear troughs were dissected along the length of the gracillis muscle, filled with BMP-saturated microfibrillar collagen, molded around a silicone tracheal stent, and left pedicled on the femoral vessels. Untreated microfibrillar collagen was buried in muscle at a distant control site in 3 animals. Autografts were susequently evaluated for lumen integrity, vascular patency, and bone induction at 3 weeks. With the exception of 2 nonviable grafts, rings of heterotopic bone were created in all 10 animals. Rings spanning at least one third of the tracheal circumference maintained a noncollapsible lumen. Microfibrillar collagen was replaced by cancellous bone that reproduced the exact shape and volume of the collagen carrier. The lumen was lined by smooth fibroplasia, and there was no significant inflammatory response, bone exposure, or overgrow...Continue Reading

Citations

Jul 31, 2014·The Journal of Laryngology and Otology·F Villegas-AlvarezJ F González-Zamora
Dec 3, 2009·Tissue Engineering. Part C, Methods·Yuchi WangHua Mao
Nov 15, 2003·British Journal of Plastic Surgery·T M MacLeodC J Green
Dec 20, 2005·The Annals of Otology, Rhinology, and Laryngology·Marita S TengMark L Urken
Oct 11, 2003·The Annals of Otology, Rhinology, and Laryngology·Pierre R Delaere, Jose Hardillo
Aug 6, 2000·British Journal of Plastic Surgery·E G LykoudisJ D Ioannovich

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