PMID: 41832Nov 1, 1979

Tracheal fluid in fetal lambs: spontaneous decrease prior to birth

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
J A KittermanW H Tooley

Abstract

We studied tracheal fluid (TF) production in 14 fetal lambs: 6 controls, 6 receiving atropine on 1 or more of the last 7 days before birth, and 2 with bilateral section of the cervical vagosympathetic trunk. A cannula diverted all TF into an intrauterine bag; we collected TF intermittently and measured its volume. All ewes delivered spontaneously at 128-150 days' gestation. TF production decreased before birth in all fetuses except one control. TF production decreased before birth in all fetuses except one control. TF production did not correlate with fetal arterial blood gas tensions, hematocrit, or plasma proteins. In controls only, TF production correlated with fetal arterial pH (P less than 0.02); however, the pH range was small and the correlation has questionable physiological significance. For all fetuses, TF production during the 7 days before birth correlated inversely with the plasma cortisol concentration of 48 h previously (n = 36; r = -0.603; P less than 0.001). We conclude a) TF production in fetal lambs decreases before spontaneous term or preterm labor; b) this decrease is not affected by atropine or by section of the cervical vagosympathetic trunk; and c) the decrease in TF production may be related to increase...Continue Reading

References

Jan 7, 1998·Journal of Applied Physiology·J J Cummings
Mar 10, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·R D Bland
Mar 7, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·A Norlin, Hans G Folkesson
Dec 3, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xin YeHans G Folkesson
Apr 21, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·J Bhatia
Nov 4, 2008·Pediatrics in Review·Lokesh GuglaniRita M Ryan
Jan 1, 1986·Pediatric Pulmonology·M G RossD A Fisher
Jan 1, 1985·Journal of Perinatal Medicine·M HallmanK Raivio
Jun 18, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·K D KalacheRainer Bollmann
Nov 17, 2006·The Journal of Pharmacology and Experimental Therapeutics·Tianbo LiHans G Folkesson
Aug 9, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Prem K NairHans G Folkesson
Oct 1, 1993·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·K A HalesG R Thurnau
Jul 1, 1999·American Journal of Respiratory Cell and Molecular Biology·M E De PaepeF I Luks
Feb 24, 2004·Annual Review of Physiology·Richard E OlverStuart M Wilson
Mar 10, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·A Norlin, Hans G Folkesson
Jan 1, 1983·Acta Paediatrica Scandinavica. Supplement·R D Bland
Jan 9, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carol J BlaisdellPaul Welling
Dec 1, 1991·Acta paediatrica Scandinavica·M GemelliF Martino
Nov 17, 2010·Experimental Lung Research·Shyny KoshyHans G Folkesson

Related Concepts

Arterial Blood pH Measurement
Fetal Structures
Body Parts - Cannula
Specimen Type - Cannula
Lung
Atropine
Trachea
Dall Sheep
Atropinum, atropine
Process of Secretion

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