PMID: 9536133Apr 16, 1998Paper

Tracheal microaspiration in adult cystic fibrosis

Journal of the Royal Society of Medicine
M J LedsonM J Walshaw

Abstract

Gastro-oesophageal reflux (GOR) has been implicated in the aetiology of lung disease. Cystic fibrosis (CF) patients have a high incidence of GOR symptoms with demonstrable episodes of oesophageal acidification. We studied 24-hour ambulatory tracheal and oesophageal pH in 11 CF patients with GOR symptoms to identify any episodes of tracheal acidification and define their temporal relation to oesophageal reflux and respiratory symptoms. 8 patients had evidence of significant GOR (DeMeester score mean 58; range 17-107) and in 6 it was gross (DeMeester score > 30). 4 patients had tracheal acidification (defined as tracheal pH < 5.5): all had greatly raised DeMeester scores. Two patterns of lowered tracheal pH were seen: a gradual drift downwards of tracheal pH to < 5.5 which recovered slowly, and an acute fall in tracheal pH to < 5.5 with rapid recovery. Only one patient had a fall in peak expiratory flow in conjunction with a decline in tracheal pH, and no association was found between the presence of tracheal microaspiration and pulmonary function. We conclude that tracheal acidification occurs in adult CF patients with GOR.

References

Nov 26, 1988·BMJ : British Medical Journal·R A NagelG D Kerr
Jun 1, 1988·The Journal of Pediatrics·S R Orenstein, D M Orenstein
Feb 1, 1985·The Journal of Pediatrics·R B ScottD G Gall
May 1, 1984·The Journal of Allergy and Clinical Immunology·H S Nelson
Feb 1, 1981·Thorax·R J GoodallJ G Temple
Apr 16, 1998·Journal of the Royal Society of Medicine·M J LedsonM J Walshaw

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Citations

Dec 21, 2005·Age and Ageing·Joanne ClaytonMargot Gosney
Apr 25, 2012·Current Gastroenterology Reports·Hayat M Mousa, Frederick W Woodley
Jun 26, 2014·Annals of the American Thoracic Society·Newell Bryce Robinson, Emily DiMango
Feb 18, 2014·BMC Pulmonary Medicine·Emily DimangoXinhua Liu
Dec 8, 2009·Journal of Pediatric Gastroenterology and Nutrition·K BlondeauD Sifrim
Jul 17, 2016·Respiratory Research·A P HackettP S McNamara
Mar 7, 2006·Gastroentérologie Clinique Et Biologique·Xavier DrayPhilippe Marteau

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