Tracing cross species transmission of Mycobacterium bovis at the wildlife/livestock interface in South Africa.

BMC Microbiology
Petronillah R SichewoAnita L Michel

Abstract

Bovine tuberculosis (bTB) affects cattle and wildlife in South Africa with the African buffalo (Syncerus caffer) as the principal maintenance host. The presence of a wildlife maintenance host at the wildlife/livestock interface acting as spill-over host makes it much more challenging to control and eradicate bTB in cattle. Spoligotyping and mycobacterial interspersed repetitive unit-variable number of tandem repeat (MIRU-VNTR) genotyping methods were performed to investigate the genetic diversity of Mycobacterium bovis (M. bovis) isolates from cattle and wildlife, their distribution and transmission at the wildlife/livestock interface in northern Kwa-Zulu Natal (KZN), South Africa. SB0130 was identified as the dominant spoligotype pattern at this wildlife/livestock interface, while VNTR typing revealed a total of 29 VNTR profiles (strains) in the KZN province signifying high genetic variability. The detection of 5 VNTR profiles shared between cattle and buffalo suggests M. bovis transmission between species. MIRU-VNTR confirmed co-infection in one cow with three strains of M. bovis that differed at a single locus, with 2 being shared with buffalo, implying pathogen introduction from most probably unrelated wildlife sources. Our...Continue Reading

References

Mar 21, 1998·Emerging Infectious Diseases·O CosiviF X Meslin
Sep 28, 2001·Journal of Clinical Microbiology·N HaddadB Durand
May 25, 2002·Emerging Infectious Diseases·Kathleen A AlexanderAnita L Michel
Feb 13, 2003·Preventive Veterinary Medicine·G M ShirimaD M Kambarage
Aug 17, 2005·Emerging Infectious Diseases·Andrea GoriFabio Franzetti
Dec 14, 2005·Veterinary Microbiology·A L MichelJ Godfroid
Jan 3, 2006·Veterinary Microbiology·Charles ThoenIsabel de Kantor
Sep 9, 2006·Epidemiology and Infection·A R RenwickR G Bengis
Dec 1, 2006·Annals of the New York Academy of Sciences·Eric EtterFrançois Roger
Aug 28, 2007·Veterinary Microbiology·A L MichelK Kremer
Jul 16, 2008·The Veterinary Record·G ZanellaB Durand
Apr 3, 2009·Preventive Veterinary Medicine·Rea TschoppJakob Zinsstag
Sep 24, 2009·Veterinary Microbiology·Anita Luise MichelPaul David van Helden
Nov 16, 2012·BMC Veterinary Research·Mudenda B Hang'ombeYasuhiko Suzuki
Apr 17, 2013·Epidemiology and Infection·M De Garine-WichatitskyA Michel
Nov 6, 2013·Transboundary and Emerging Diseases·M V Palmer
Mar 26, 2014·Nature Reviews. Genetics·James E Galagan
Feb 20, 2015·Emerging Infectious Diseases·Jolly MusokeAnita L Michel
Jan 19, 2018·PLoS Neglected Tropical Diseases·Adelina MachadoMargarida Correia-Neves
Dec 2, 2019·Preventive Veterinary Medicine·Petronillah R SichewoAnita L Michel

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Citations

Jan 8, 2021·Frontiers in Genetics·Alexander Stephen ByrneKapil Tahlan
Feb 16, 2021·Frontiers in Veterinary Science·Netanya BernitzMichele A Miller
Apr 13, 2021·Frontiers in Veterinary Science·David J KellyMargaret Good

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Excel
Bionumerics

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