Tracing pharmaceutical residues of different therapeutic classes in environmental waters by using liquid chromatography/quadrupole-linear ion trap mass spectrometry and automated library searching

Analytical Chemistry
Meritxell GrosDamià Barceló

Abstract

This article describes the development, optimization, and validation of an analytical method for the simultaneous detection and identification of 73 pharmaceutical residues, covering various therapeutic groups, in both surface and wastewaters. The method is based on the simultaneous extraction of all target compounds by Solid Phase Extraction (SPE), using a hydrophilic-lipophilic balanced polymer followed by liquid chromatography tandem mass spectrometry, using a hybrid triple quadrupole-linear ion trap mass spectrometer (QqLIT). Quantitative analysis was performed using the 4000 Qtrap tandem mass spectrometer in Selected Reaction Monitoring (SRM) mode, monitoring two SRM transitions to fulfill EC guidelines, as well as to ensure an accurate identification of target compounds in the samples. Quantitation is performed by the internal standard approach, indispensable to correct matrix effects. Moreover, to obtain an extra tool for confirmation and identification of the studied pharmaceuticals, an Information Dependent Acquisition (IDA) experiment was performed, with SRM as the survey scan and an enhanced product ion (EPI) scan, at three different collision energies, as dependent scan. Compound identification was carried out by li...Continue Reading

References

Aug 6, 1998·Journal of Chromatography. a·W M Niessen
Dec 11, 1999·Environmental Health Perspectives·C G Daughton, T A Ternes
Apr 30, 2003·Rapid Communications in Mass Spectrometry : RCM·James W Hager, J C Yves Le Blanc
Aug 27, 2004·Journal of Mass Spectrometry : JMS·Gérard HopfgartnerLuc Alexis Leuthold
Jul 27, 2005·Water Research·Adriano JossHansruedi Siegrist
May 19, 2006·Analytical and Bioanalytical Chemistry·M Silvia Díaz-Cruz, Damià Barceló
Nov 23, 2006·Analytical and Bioanalytical Chemistry·Jelena RadjenovicDamiá Barceló
Jan 5, 2007·Analytical and Bioanalytical Chemistry·M FarréD Barceló
Mar 31, 2007·Rapid Communications in Mass Spectrometry : RCM·Hendrik De Ruyck, Herman De Ridder

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Citations

Jul 8, 2011·Environmental Science and Pollution Research International·Antoni GinebredaDamià Barceló
May 1, 2012·Environmental Science and Pollution Research International·Victoria OsorioDamià Barceló
Apr 8, 2011·Journal of the American Society for Mass Spectrometry·Miao WangMilton L Lee
Mar 10, 2011·Environmental Science & Technology·Sihem Ben AbdelmelekWeihua Song
Nov 11, 2014·Environmental Science and Pollution Research International·M J Martínez BuenoE Gómez
Oct 9, 2014·Membranes·Matthias de CazesJosé Sanchez-Marcano
Jan 24, 2016·The Science of the Total Environment·Camilo D Seabra PereiraLuciana L Guimarães
Feb 22, 2013·The Science of the Total Environment·Héctor Del RíoPablo Ures
Jan 5, 2013·The Science of the Total Environment·Sheyla Ortiz de GarcíaRubén Irusta Mata
Jan 8, 2013·The Science of the Total Environment·Fumie AdachiRyuji Kawahara
Apr 6, 2012·Journal of Hazardous Materials·Davor DolarDamià Barceló
Aug 13, 2010·Journal of Hazardous Materials·Dolores Camacho-MuñozEsteban Alonso
Apr 17, 2010·Journal of Hazardous Materials·Christina I KosmaTriantafyllos A Albanis
Dec 22, 2009·Environment International·Silvia González AlonsoYolanda Valcárcel
Sep 29, 2012·Journal of Mass Spectrometry : JMS·Chengtao Wang, Piero R Gardinali
Jun 5, 2013·The Science of the Total Environment·Lúcia H M L M SantosM Conceição B S M Montenegro

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