Tracing the emerging genotypes of human respiratory syncytial virus in Beijing by evolution analysis of the attachment glycoprotein (G) gene

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Tuohui ZhangLinqing Zhao

Abstract

Emerging human respiratory syncytial virus (HRSV) genotypes, such as ON1 and BA9, are becoming the dominant genotypes prevailing worldwide. Objective To trace the emerging HRSV genotypes in Beijing. HRSV-positive specimens as determined by direct immunofluorescence, collected from children diagnosed with bronchiolitis from July 2006 to June 2016, were typed by real-time PCR, then genotyped by phylogenetic analyses of the full attachment glycoprotein (G) gene. A Bayesian skyline plot was constructed to analyze the population dynamics for identified HRSV strains, and selective pressure was analyzed. The previous dominant HRSV A genotype, NA1, was replaced by ON1 in 2014. BA9 was the dominant HRSV B genotype for the duration of the study. The time to the most recent common ancestor (tMRCA) for HRSV A is since the 1943-1944 season; for the genotypes NA1 and ON1, since the 1999-2000 season and 2010-2011 season, respectively. The tMRCA for HRSV B is since the 1956-1957 season; for the genotypes BA and BA9, from the 1998-1999 season and 2005-2006 season, respectively. The mean evolutionary rate of HRSV A (3.65 × 10-3) was faster than those of HRSV B (3.11 × 10-3), and the genotypes NA1 (2.01 × 10-3) and ON1 (1.66 × 10-3). The estimate...Continue Reading

Citations

Sep 16, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·M JagusicD Forcic
Feb 12, 2021·Scientific Reports·Juan C Muñoz-EscalanteDaniel E Noyola
Apr 19, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Amary FallNdongo Dia
May 22, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Wint Wint PhyuHisami Watanabe
Jun 17, 2021·Archives of Virology·Yingying MaChiyu Zhang

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