Tracing thymic output in older individuals.

Clinical and Experimental Immunology
Wayne A MitchellR Aspinall

Abstract

As a result of age-associated thymic atrophy, T cell production declines with age. Some studies suggest that production undergoes an exponential decline starting at birth, while others consider the decline to be in a biphasic manner with a rapid reduction in output occurring before middle age followed by a phase in which output declines at a regular, albeit much slower, rate. Both approaches provide estimations of the time of termination of thymic output, but on the basis of limited amounts of data. We have analysed blood from more than 200 individuals between the ages of 58 and 104 years to determine changes in thymic output using signal-joint T cell receptor excision circles (sjTREC)/T cells as our measure. To reduce any potential geographical or nutritional bias we have obtained samples from five different European countries. Our results reveal that while the absolute number of T cells per microlitre of blood does not change significantly across the age range we tested, the values of sjTREC per microlitre show wide variation and reveal an age-associated decline in thymic output. In addition we show gender differences, with notably higher thymic output in females than males at each decade. More importantly, we noted a signifi...Continue Reading

References

Jan 1, 1986·Current Topics in Pathology. Ergebnisse Der Pathologie·G G Steinmann
Jun 1, 1974·Klinische Wochenschrift·F Trepel
Jun 1, 1996·Immunology Today·A J George, M A Ritter
Feb 10, 1999·Seminars in Immunology·M A Ritter, D B Palmer
Apr 24, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K Schmader
Jun 16, 2001·The New England Journal of Medicine·D NashUNKNOWN 1999 West Nile Outbreak Response Working Group
Sep 5, 2001·Clinical and Experimental Immunology·J Pido-LopezR Aspinall
May 7, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Graham PawelecRafael Solana
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria Saurwein-TeisslBeatrix Grubeck-Loebenstein
Oct 2, 2002·European Journal of Immunology·Jeffrey Pido-LopezRichard Aspinall
Jan 9, 2003·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Sep 27, 2003·Journal of the American Geriatrics Society·Gerbrand J IzaksRudi G J Westendorp
Jun 3, 2004·Human Immunology·Paul Moss, Naeen Khan
Jul 28, 2004·Trends in Immunology·Graham PawelecAnders Wikby
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keith NaylorJörg J Goronzy
Jan 27, 2006·The Journal of Molecular Diagnostics : JMD·Barbara DessarsHakim El Housni
May 30, 2006·PLoS Medicine·José María GutiérrezDavid A Warrell
Jun 29, 2006·Annals of the New York Academy of Sciences·Gerald PfisterBeatrix Grubeck-Loebenstein
Oct 25, 2006·Journal of Clinical and Experimental Hematopathology : JCEH·Yoshie ShimoyamaShigeo Nakamura
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Luka Cicin-SainJanko Nikolich-Zugich
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryan D KilpatrickBeth D Jamieson
Apr 18, 2008·Experimental Gerontology·Eugenio MocchegianiTamas Fulop
Dec 17, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kevin P HighThomas T Yoshikawa
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mushtaq AhmedMarcia A Blackman
Apr 8, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Michele MusciRoland Hetzer
Jun 23, 2009·Trends in Immunology·Nan-Ping WengJorg Goronzy
Dec 4, 2009·Journal of Comparative Pathology·R AspinallW Mitchell

❮ Previous
Next ❯

Citations

Jul 21, 2011·Biogerontology·Danielle Aw, Donald B Palmer
Apr 6, 2012·Immunologic Research·Paulina Dominika RymkiewiczAnis Larbi
Aug 24, 2012·PLoS Pathogens·Andrea MekkerUrs Karrer
Jul 24, 2013·Age·Rita RezzaniLuigi Fabrizio Rodella
Nov 21, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stéphane BlancheFlorence Buseyne
Mar 1, 2012·Age·Pierre Olivier LangRichard Aspinall
Aug 30, 2011·Current Opinion in Immunology·Jianwei WangK Lenhard Rudolph
Oct 5, 2010·Ageing Research Reviews·Pierre-Olivier LangRichard Aspinall
May 23, 2014·Biochemical Society Transactions·Richard AspinallPierre O Lang
Aug 8, 2012·Journal of Immunological Methods·Pierre-Olivier LangRichard Aspinall
Sep 3, 2013·Current Opinion in Immunology·Scott D BoydDeborah K Dunn-Walters
Oct 15, 2013·Experimental Gerontology·Cristina FalciVittorina Zagonel
Jan 1, 2014·Mechanisms of Ageing and Development·Mònica MaijóSimon R Carding
Sep 1, 2012·Blood·Doron Melamed, David W Scott
May 27, 2016·American Journal of Veterinary Research·Qian ZhangYan Cui
Jun 1, 2016·Scientific Reports·Marieke van der HeidenAnne-Marie Buisman
Jun 9, 2016·Clinical Reviews in Allergy & Immunology·Frédérique TruffaultSonia Berrih-Aknin
Jun 24, 2016·Biodemography and Social Biology·Lydia FeinsteinAllison E Aiello
Jan 31, 2017·Vaccines·Marco Cavallari, Gennaro De Libero
Aug 8, 2015·Scientific Reports·Maude Dumont-LagacéClaude Perreault
May 26, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kyosuke SatoNagahiro Minato
Oct 6, 2011·Current Opinion in Allergy and Clinical Immunology·Raz Somech
Nov 29, 2017·Expert Review of Vaccines·Richard Aspinall, Pierre Olivier Lang
Jan 31, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maude Dumont-LagacéClaude Perreault
Sep 26, 2020·Frontiers in Immunology·Jastaranpreet SinghJuan Carlos Zúñiga-Pflücker
Jun 4, 2014·Expert Review of Vaccines·Richard Aspinall, Pierre Olivier Lang
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wilfred Ndifon, Jonathan Dushoff
Feb 15, 2018·Frontiers in Endocrinology·Gordana Momčilo Leposavić, Ivan M Pilipović
Jun 2, 2020·Frontiers in Immunology·Jennifer E CowanIzumi Ohigashi
Mar 16, 2021·Frontiers in Immunology·Kieran D JamesGraham Anderson
Jan 14, 2020·Autoimmunity Reviews·Judith MerrheimNadine Dragin
Jun 1, 2021·Frontiers in Oncology·Xinyi HuangJiandong Zhang
Jun 3, 2021·Cancers·Meriem Ben KhoudCarine Brinster

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.