Tracking a molecular motor with a nanoscale optical encoder.

Nano Letters
Charles E WickershamEverett A Lipman

Abstract

Optical encoders are commonly used in macroscopic machines to make precise measurements of distance and velocity by translating motion into a periodic signal. Here we show how Forster resonance energy transfer can be used to implement this technique at the single-molecule scale. We incorporate a series of acceptor dye molecules into self-assembling DNA, and the periodic signal resulting from unhindered motion of a donor-labeled molecular motor provides nanometer-scale resolution in milliseconds.

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Citations

Aug 5, 2010·Quarterly Reviews of Biophysics·Jaya G YodhTaekjip Ha
Nov 13, 2010·Nucleic Acids Research·Nicholas LuzziettiRalf Seidel
Nov 6, 2015·Critical Reviews in Biochemistry and Molecular Biology·Bo Sun, Michelle D Wang
May 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Herschel M WatkinsKevin W Plaxco
Sep 26, 2014·Current Opinion in Structural Biology·Juan Carlos CordovaMatthew J Lang
Aug 6, 2010·Physical Biology·Johannes HohlbeinAchillefs N Kapanidis
Nov 13, 2010·Bioconjugate Chemistry·Charles E WickershamEverett A Lipman
Oct 5, 2018·The Journal of Physical Chemistry. B·Charles E Wickersham, Everett A Lipman

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