Tracking kidney volume in mice with polycystic kidney disease by magnetic resonance imaging

Kidney International
Darren P WallaceMehmet Bilgen

Abstract

Polycystic kidney disease is characterized by the progressive enlargement of kidneys due to expanding fluid-filled cysts with the rate of renal volume increase held to be a marker of disease progression. Magnetic resonance imaging (MRI) is used to monitor changes in renal volume in patients with polycystic kidney disease; however, it has not been effectively used in mice to monitor changes in kidney volume during drug treatment studies. We used a powerful 9.4-T horizontal bore magnetic resonance scanner to track changes in kidney volume in pcy/pcy mice, an ortholog of nephronophthisis type 3. Mice were sequentially scanned from 4 to 30 weeks of age and kidney volumes determined from high-resolution images. Kidney volume and maximal cross-sectional surface area correlated positively with kidney weight and the histologic determination of surface area. The increase in kidney volume was exponential up to 20 weeks of age, after which there was a plateau consistent with the replacement of normal parenchyma by fibrotic tissue. Our study demonstrates that MRI accurately determines the rate of kidney volume increase in mice with polycystic kidney disease and hence may be useful in assessing the effectiveness of therapeutic agents to slo...Continue Reading

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Citations

Apr 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R Brian DoctorCharles L Edelstein
Mar 30, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maliha SadickDaniel Schock-Kusch
Oct 17, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Ian Wu, Chirag R Parikh
Oct 16, 2008·Kidney International·Vinitha A JacobStasia A Anderson
Nov 29, 2013·Kidney International·Darren P WallaceTimothy A Fields
Apr 18, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jared J Grantham
Jul 16, 2008·Contrast Media & Molecular Imaging·M AlmajdubM Janier
May 15, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Timothy L KlineBradley J Erickson
Aug 2, 2011·European Journal of Radiology·Maria KalogerouMing Hong Shen
Oct 10, 2014·PloS One·Astrid VelroyenMike Notohamiprodjo
Oct 18, 2018·American Journal of Physiology. Renal Physiology·Archana RamanDarren P Wallace
May 20, 2017·Journal of the American Society of Nephrology : JASN·Archana RamanDarren P Wallace
Nov 10, 2017·Journal of the American Society of Nephrology : JASN·Kristen L NowakMichel Chonchol
Nov 5, 2019·American Journal of Physiology. Renal Physiology·Faith OmedeJason R Stubbs
Nov 10, 2020·American Journal of Physiology. Renal Physiology·Yan ZhangDarren P Wallace
Jun 13, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Kristen L NowakMichel B Chonchol

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