PMID: 6413098Jul 1, 1983Paper

Tracking of indium-111-oxine labelled lymphocytes in autoimmune thyroid disease

Clinical Endocrinology
P PozzilliA G Cudworth

Abstract

Peripheral lymphocytes (approximately 10(8)) from 4 subjects affected by autoimmune thyroid disease (2 Hashimoto's thyroiditis, 1 primary myxoedema, 1 Graves' disease) and 4 normal subjects were labelled in vitro with 40 microCi of indium-111-oxine and, following autologous injection, the distribution of the cells in the body was investigated by gamma camera imaging. Lymphocytes in the thyroid were observed 24 h after injection in both patients with Hashimoto's thyroiditis and in the patient with primary myxoedema, but not in the patient with Graves' disease or in any of the controls. To our knowledge, this is the first report using this method to try and demonstrate lymphocytes in the thyroid gland, and supports the concept that cell-mediated immunity may be playing an important role in the pathogenesis of Hashimoto's thyroiditis and primary myxoedema.

References

Jul 28, 1979·Lancet·P PozzilliA G Cudworth
Mar 1, 1978·Clinics in Endocrinology and Metabolism·R Volpé
Jan 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·P FrostH Frost
Aug 1, 1981·European Journal of Clinical Investigation·D Doniach

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Citations

Jun 11, 2008·European Journal of Nuclear Medicine and Molecular Imaging·M ChianelliA Signore
Nov 8, 2001·Experimental Hematology·J R Allport, R Weissleder
Mar 11, 2004·Thyroid : Official Journal of the American Thyroid Association·K JungheimP M Schumm-Draeger
Apr 9, 2008·Stem Cells and Development·Dawn M DeloShay Soker
Jan 1, 1992·Thyroid : Official Journal of the American Thyroid Association·A Martin, T F Davies
May 24, 2011·World Journal of Clinical Oncology·Ali Syed Arbab
Mar 5, 2004·Expert Opinion on Biological Therapy·Michel ModoSteve C R Williams
Jun 9, 2004·Neuroimaging Clinics of North America·Dawid Schellingerhout, Lee Josephson
Mar 1, 1985·Stroke; a Journal of Cerebral Circulation·C PozzilliP Pozzilli
Aug 28, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Alberto SignoreFrancesco Scopinaro
Apr 9, 1999·Journal of Endocrinological Investigation·A SignoreR Barone
May 1, 1997·European Journal of Nuclear Medicine·J KuyamaA M Peters

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