Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection

Immunity
Stephen J McSorleyMarc K Jenkins

Abstract

A novel adoptive transfer system was used to track the fate of naive Salmonella-specific CD4 T cells in vivo. These cells showed signs of activation in the Peyer's patches as early as 3 hr after oral infection. The activated CD4 T cells then produced IL-2 and proliferated in the T cell areas of these tissues before migrating into the B cell-rich follicles. In contrast, Salmonella-specific CD4 T cells were not activated in the spleen and very few of these cells migrated to the liver, despite the presence of bacteria in both organs. These results show that the T cell response to pathogenic Salmonella infection is localized to the gut-associated lymphoid tissue and does not extend efficiently to the major sites of late infection.

References

May 1, 1974·The Journal of Experimental Medicine·P B Carter, F M Collins
Aug 1, 1995·Current Opinion in Immunology·B JonesS Falkow
Mar 27, 1995·Journal of Immunological Methods·V KouskoffD Mathis
Jan 1, 1996·Annual Review of Immunology·B D Jones, S Falkow
Apr 1, 1996·Current Opinion in Immunology·M G McHeyzer-WilliamsM M Davis
Oct 1, 1996·European Journal of Immunology·C R MackayE C Butcher
Jun 16, 1997·The Journal of Experimental Medicine·E IngulliM K Jenkins
May 23, 1998·Annual Review of Immunology·R W DuttonS L Swain
Nov 26, 1999·Immunology and Cell Biology·C R Parish
Mar 10, 2001·Nature·R L ReinhardtM K Jenkins
Mar 13, 2001·Annual Review of Immunology·M K JenkinsK A Pape
Jun 1, 1959·Journal of General Microbiology·B A STOCKER, J C CAMPBELL

❮ Previous
Next ❯

Citations

Jun 25, 2005·Immunology Letters·Rosa Maria Salazar-Gonzalez, Stephen J McSorley
Jun 6, 2003·Current Opinion in Immunology·Linda M Bradley
Aug 6, 2003·Current Opinion in Immunology·R Lee Reinhardt, Marc K Jenkins
Aug 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·William W ReileyDavid L Woodland
Jun 30, 2005·Animal Health Research Reviews·Els N T MeeusenGary Entrican
Oct 9, 2002·The Journal of Experimental Medicine·Eulogia RománSusan L Swain
Oct 22, 2003·The Journal of Experimental Medicine·Gianluca RottaMaria Rescigno
Feb 9, 2005·Current Opinion in Gastroenterology·Stavros Sougioultzis, Charalabos Pothoulakis
Dec 16, 2004·Transplantation·Kim S JonesReginald M Gorczynski
Nov 29, 2007·Current Opinion in Gastroenterology·Guntram A Grassl, B Brett Finlay
Sep 4, 2008·Infection and Immunity·Douglas M HeithoffMichael J Mahan
Apr 23, 2008·Infection and Immunity·Jennifer L BishopB Brett Finlay
Mar 24, 2007·Annual Review of Immunology·Akiko Iwasaki
Nov 20, 2002·The Journal of Clinical Investigation·Stephanie L ConstantKim Bottomly
Dec 11, 2008·BMC Microbiology·Sandra S OjedaJudy M Teale
Feb 5, 2010·Journal of Leukocyte Biology·Jeremy P McAleerAnthony T Vella
Jan 10, 2013·PloS One·William E JenkinsonGraham Anderson
Sep 24, 2010·Future Microbiology·Beena JohnChristopher A Hunter
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Nadia R RoanMichael N Starnbach
Jul 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rajesh RavindranStephen J McSorley
Jun 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Claudia RollenhagenDirk Bumann
Oct 24, 2012·Immunology Letters·Seung-Joo LeeStephen J McSorley
Feb 15, 2011·Vaccine·Amanda J Griffin, Stephen J McSorley
May 5, 2009·Methods : a Companion to Methods in Enzymology·Elena PettiniDonata Medaglini
Dec 25, 2010·European Journal of Immunology·Shirdi E LetranStephen J McSorley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.