Tracking stem cells for cellular therapy in stroke.

Current Pharmaceutical Design
Nathan C Manley, Gary Steinberg

Abstract

Stem cell transplantation has emerged as a promising treatment strategy for stroke. The development of effective ways to monitor transplanted stem cells is essential to understand how stem cell transplantation enhances stroke recovery and ultimately will be an indispensable tool for advancing stem cell therapy to the clinic. In this review, we describe existing methods of tracking transplanted stem cells in vivo, including optical imaging, magnetic resonance imaging (MRI), and positron emission tomography (PET), with emphasis on the benefits and drawbacks of each imaging approach. Key considerations such as the potential impact of each tracking system on stem cell function, as well as its relative applicability to humans are discussed. Finally, we describe multi-modal imaging strategies as a more comprehensive method to track transplanted stem cells in the stroke-injured brain.

Citations

Jun 25, 2013·Tissue Engineering. Part C, Methods·Jean-Baptiste SouronSibylle Opsahl Vital
Apr 19, 2013·Neurological Research·Liuqing WangKunlin Jin
Dec 18, 2013·Progress in Neurobiology·Xinfeng LiuJieli Chen
Oct 19, 2013·Current Opinion in Neurology·Robin Lemmens, Gary K Steinberg
Feb 4, 2019·Current Neurology and Neuroscience Reports·Ania DabrowskiRyan J Felling
Nov 27, 2020·Drug Discovery Today·Deepaneeta SarmahPallab Bhattacharya
Jul 9, 2021·Frontiers in Cellular Neuroscience·Guini SongYue He

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