Tracking the Fate of Porous Silicon Nanoparticles Delivering a Peptide Payload by Intrinsic Photoluminescence Lifetime

Advanced Materials
Yusung JinJinmyoung Joo

Abstract

A nanoparticle system for systemic delivery of therapeutics is described, which incorporates a means of tracking the fate of the nanocarrier and its residual drug payload in vivo by photoluminescence (PL). Porous silicon nanoparticles (PSiNPs) containing the proapoptotic antimicrobial peptide payload, D [KLAKLAK]2 , are monitored by measurement of the intrinsic PL intensity and the PL lifetime of the nanoparticles. The PL lifetime of the PSiNPs is on the order of microseconds, substantially longer than the nanosecond lifetimes typically exhibited by conventional fluorescent tags or by autofluorescence from cells and tissues; thus, emission from the nanoparticles is readily discerned in the time-resolved PL spectrum. It is found that the luminescence lifetime of the PSiNP host decreases as the nanoparticle dissolves in phosphate-buffered saline solution (37 °C), and this correlates with the extent of release of the peptide payload. The time-resolved PL measurement allows tracking of the in vivo fate of PSiNPs injected (via tail vein) into mice. Clearance of the nanoparticles through the liver, kidneys, and lungs of the animals is observed. The luminescence lifetime of the PSiNPs decreases with increasing residence time in the mi...Continue Reading

References

Aug 2, 1996·Journal of Medicinal Chemistry·M M JavadpourM L McLaughlin
Jun 5, 2007·Journal of Pharmaceutical Sciences·Jarno SalonenVesa-Pekka Lehto
May 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hongtao ChenJi-Xin Cheng
Feb 12, 2009·ACS Nano·Folarin ErogbogboMark T Swihart
Feb 24, 2009·Nature Materials·Ji-Ho ParkMichael J Sailor
Mar 3, 2009·Biomaterials·Suet P LowKeryn A Williams
Apr 1, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tessa M ScownCharles R Tyler
Oct 31, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·P DecuzziM Ferrari
Jul 8, 2010·Angewandte Chemie·Jae-Hyun LeeJinwoo Cheon
Jul 21, 2010·Nanoscale·Rita E SerdaMauro Ferrari
Sep 8, 2010·Nanoscale·Silvia FerratiRita E Serda
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chung Hang J ChoiMark E Davis
Feb 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jonathan E ZuckermanMark E Davis
Jul 14, 2012·Nanoscale Research Letters·Dolf Timmerman, Tom Gregorkiewicz
Jul 12, 2014·ACS Applied Materials & Interfaces·Brian T Luk, Liangfang Zhang
Jan 27, 2015·Chemical Society Reviews·Otto S Wolfbeis
Mar 18, 2015·Chemical Society Reviews·Jing ZhengWeihong Tan
Mar 27, 2015·Nano Letters·Ryan M WilliamsDaniel A Heller
Jun 3, 2015·ACS Nano·Jinmyoung JooMichael J Sailor
Jan 18, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yi-Nan ZhangWarren C W Chan
Oct 26, 2016·Nature Materials·Kim M TsoiWarren C W Chan
Dec 17, 2016·Nanotechnology·Ilya SychugovJan Linnros
Jan 4, 2017·ACS Nano·Sonya A MacParlandIan D McGilvray
Dec 27, 2017·ACS Applied Materials & Interfaces·Joanna WangMichael J Sailor
Sep 1, 2016·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Jinmyoung JooMichael J Sailor
Jun 30, 2018·Nature Biomedical Engineering·Sazid HussainErkki Ruoslahti

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Citations

Aug 9, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yoonsang ParkJinmyoung Joo
Jan 1, 2020·Current Protein & Peptide Science·Sk Abdul Mohid, Anirban Bhunia
Jun 9, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Rae Hyung KangHyo Young Kim
Jul 23, 2021·ACS Biomaterials Science & Engineering·Ruoyu ChengHélder A Santos

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