Tracking viral evolution during a disease outbreak: the rapid and complete selective sweep of a circovirus in the endangered Echo parakeet.

Journal of Virology
Samit KunduJim J Groombridge

Abstract

Circoviruses are among the smallest and simplest of all viruses, but they are relatively poorly characterized. Here, we intensively sampled two sympatric parrot populations from Mauritius over a period of 11 years and screened for the circovirus Beak and feather disease virus (BFDV). During the sampling period, a severe outbreak of psittacine beak and feather disease, which is caused by BFDV, occurred in Echo parakeets. Consequently, this data set presents an ideal system for studying the evolution of a pathogen in a natural population and to understand the adaptive changes that cause outbreaks. Unexpectedly, we discovered that the outbreak was most likely caused by changes in functionally important regions of the normally conserved replication-associated protein gene and not the immunogenic capsid. Moreover, these mutations were completely fixed in the Echo parakeet host population very shortly after the outbreak. Several capsid alleles were linked to the replication-associated protein outbreak allele, suggesting that whereas the key changes occurred in the latter, the scope of the outbreak and the selective sweep may have been influenced by positive selection in the capsid. We found evidence for viral transmission between the...Continue Reading

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Citations

Dec 19, 2014·Avian Diseases·Elena CircellaAntonio Camarda
Sep 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Justin R EastwoodAndrew T D Bennett
Feb 8, 2014·Virology·Gordon W HarkinsArvind Varsani
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Oct 17, 2019·Avian Pathology : Journal of the W.V.P.A·Susanne KesslerDennis Rubbenstroth
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Oct 19, 2017·Scientific Reports·Justin R EastwoodMathew L Berg
Dec 5, 2020·Viral Immunology·Babu Kanti NathJade K Forwood

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