Tracting the neural basis of music: Deficient structural connectivity underlying acquired amusia

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Aleksi J SihvonenSeppo Soinila

Abstract

Acquired amusia provides a unique opportunity to investigate the fundamental neural architectures of musical processing due to the transition from a functioning to defective music processing system. Yet, the white matter (WM) deficits in amusia remain systematically unexplored. To evaluate which WM structures form the neural basis for acquired amusia and its recovery, we studied 42 stroke patients longitudinally at acute, 3-month, and 6-month post-stroke stages using DTI [tract-based spatial statistics (TBSS) and deterministic tractography (DT)] and the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA). Non-recovered amusia was associated with structural damage and subsequent degeneration in multiple WM tracts including the right inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus (AF), inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF), and frontal aslant tract (FAT), as well as in the corpus callosum (CC) and its posterior part (tapetum). In a linear regression analysis, the volume of the right IFOF was the main predictor of MBEA performance across time. Overall, our results provide a comprehensive picture of the large-scale deficits in intra- and interhemispheric struc...Continue Reading

Citations

Nov 19, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Angela D Friederici
Mar 2, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Maja KlarendićMaja Kojović
Mar 19, 2021·Frontiers in Neurology·Emanuele La CorteGraziano Serrao
Mar 30, 2021·Frontiers in Neuroscience·Alicja M OlszewskaArtur Marchewka
Aug 17, 2019·NeuroImage. Clinical·Vera LeoTeppo Särkämö
Oct 19, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Aleksi J SihvonenTeppo Särkämö

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