Tractography Study of Deep Brain Stimulation of the Anterior Cingulate Cortex in Chronic Pain: Key to Improve the Targeting

World Neurosurgery
Sandra G J BoccardTipu Z Aziz

Abstract

Deep brain stimulation (DBS) of the anterior cingulate cortex (ACC) is a new treatment for alleviating intractable neuropathic pain. However, it fails to help some patients. The large size of the ACC and the intersubject variability make it difficult to determine the optimal site to position DBS electrodes. The aim of this work was therefore to compare the ACC connectivity of patients with successful versus unsuccessful DBS outcomes to help guide future electrode placement. Diffusion magnetic resonance imaging (dMRI) and probabilistic tractography were performed preoperatively in 8 chronic pain patients (age 53.4 ± 6.1 years, 2 females) with ACC DBS, of whom 6 had successful (SO) and 2 unsuccessful outcomes (UOs) during a period of trialing. The number of patients was too small to demonstrate any statistically significant differences. Nevertheless, we observed differences between patients with successful and unsuccessful outcomes in the fiber tract projections emanating from the volume of activated tissue around the electrodes. A strong connectivity to the precuneus area seems to predict unsuccessful outcomes in our patients (UO: 160n/SO: 27n), with (n), the number of streamlines per nonzero voxel. On the other hand, connectivi...Continue Reading

References

Apr 22, 1991·Proceedings. Biological Sciences·A K JonesR S Frackowiak
Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Mar 1, 1996·Electroencephalography and Clinical Neurophysiology·T AllisonD D Spencer
Sep 1, 1999·Brain : a Journal of Neurology·R PeyronB Laurent
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·T E ConturoM E Raichle
Dec 29, 2000·Neurophysiologie clinique = Clinical neurophysiology·R PeyronL García-Larrea
May 22, 2001·The Anatomical Record·G R Leichnetz
Jan 16, 2002·Pain·Predrag Petrovic, Martin Ingvar
Jul 26, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·D E BentleyA K P Jones
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Nov 1, 1952·Electroencephalography and Clinical Neurophysiology·P D MACLEAN
Jan 20, 2004·Nature Neuroscience·Hugo D CritchleyRaymond J Dolan
Apr 27, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Richard G BittarTipu Z Aziz
Jul 5, 2005·Nature Reviews. Neuroscience·Brent A Vogt
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Jun 17, 2006·Annual Review of Neuroscience·Joel S Perlmutter, Jonathan W Mink
Jul 20, 2007·Nature Reviews. Neuroscience·Morten L KringelbachTipu Z Aziz
Dec 20, 2008·Nature Reviews. Neuroscience·A D Bud Craig
Jan 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthias BeckmannMatthew F S Rushworth
Oct 7, 2009·Neurobiology of Disease·Cameron C McIntyre, Philip J Hahn
Nov 3, 2010·The European Journal of Neuroscience·Morten L KringelbachTipu Z Aziz
May 18, 2011·Frontiers in Integrative Neuroscience·Morten L KringelbachTipu Z Aziz
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Jan 1, 2011·Brain Connectivity·Saad Jbabdi, Heidi Johansen-Berg
May 23, 2012·Neuroscience and Biobehavioral Reviews·Santino Gaudio, Carlo Cosimo Quattrocchi
Aug 29, 2012·Neurology·Fan-Gang MengRudiger Hilker
Sep 11, 2012·Brain : a Journal of Neurology·Xiaosi GuJin Fan
Nov 15, 2012·Neurosurgery·Sandra G J BoccardAlexander L Green
May 3, 2013·Brain Topography·Philippe GoffauxKevin Whittingstall
May 31, 2013·Nature Reviews. Neuroscience·M Catherine BushnellLucie A Low
Jun 26, 2013·Stereotactic and Functional Neurosurgery·Erlick A C PereiraAlexander L Green
Nov 10, 2013·British Journal of Neurosurgery·Erlick A C PereiraTipu Z Aziz

❮ Previous
Next ❯

Citations

Jul 26, 2016·Frontiers in Neuroanatomy·Jennifer A SweetJonathan P Miller
May 18, 2016·World Neurosurgery·Laurie PycroftTipu Z Aziz
Oct 17, 2017·Frontiers in Surgery·Angela An Qi See, Nicolas Kon Kam King
Aug 30, 2017·Stereotactic and Functional Neurosurgery·Max Ward, Antonios Mammis
Feb 11, 2021·Neuroscience Bulletin·Xiao XiaoYu-Qiu Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.