Trade-off between iron uptake and protection against oxidative stress: deletion of cueO promotes uropathogenic Escherichia coli virulence in a mouse model of urinary tract infection.

Journal of Bacteriology
Jai J TreeMark A Schembri

Abstract

The periplasmic multicopper oxidase (CueO) is involved in copper homeostasis and protection against oxidative stress. Here, we show that the deletion of cueO in uropathogenic Escherichia coli increases its colonization of the urinary tract despite its increased sensitivity to hydrogen peroxide. The cueO deletion mutant accumulated iron with increased efficiency compared to its parent strain; this may account for its advantage in the iron-limited environment of the urinary tract.

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Citations

Feb 22, 2012·Cell Host & Microbe·Marie I SamanovicK Heran Darwin
Dec 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sargurunathan SubashchandraboseHarry L T Mobley
May 27, 2015·Critical Reviews in Microbiology·Alison J CareyGlen C Ulett
Feb 14, 2015·Metallomics : Integrated Biometal Science·Sargurunathan Subashchandrabose, Harry L T Mobley
Jun 10, 2015·The Journal of Biological Chemistry·Karrera Y DjokoAlastair G McEwan
Aug 28, 2020·PLoS Pathogens·Panatda SaenkhamSargurunathan Subashchandrabose
May 27, 2016·Microbiology Spectrum·Evgeni Sokurenko

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