Trade-offs in the development of various dosage form (overview)

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Takahiro Uchida

Abstract

In this symposium we focused on trade-offs which might occur in the process of development of many types of formulation and corresponding dissolution methods. Firstly, we focused on a solubility-permeability trade-off in the case of micelle with surfactant or molecular complex with CyD. The micelle would be successful in increasing drug solubility, however it rather decreased permeability of model drug progesterone (Biopharmaceutics Classfication System (BCS) Class II) as an overall flux. Secondly in order to reduce bitterness of branched chain amino acid (BCAA), increasing particle sizes of each amino acid crystals involved in formulation was effective since the release rate of amino acid was restricted efficiently. Thirdly, in the case of injection of paclitaxel (BCS Class II)formulation, the drug was adsorbed to albumin. Thereby the risk of allergy was dramatically decreased compared to the case when non-ionic surfactant was used as an additive. Fourth, anticancer drug was incorporated into the internal (core) phase of an orally disintegrating tablet (ODT), this is also merit to avoid exposure of the drug to a nursing person or individual working person in manufacturing process. Fifth, the convenient syringe type kit pharmac...Continue Reading

References

Aug 6, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Takayuki YoshidaTakahiro Uchida
Sep 16, 2008·International Journal of Pharmaceutics·T YoshidaT Uchida
Jan 23, 2009·Archives of Disease in Childhood. Fetal and Neonatal Edition·A WhittakerH C Pandya
Jun 19, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Avital BeigArik Dahan

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