Tradeoffs and constraints on neural representation in networks of cortical neurons.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Einat KermanyDanny Eytan

Abstract

Neural representation is pivotal in neuroscience. Yet, the large number and variance of underlying determinants make it difficult to distinguish general physiologic constraints on representation. Here we offer a general approach to the issue, enabling a systematic and well controlled experimental analysis of constraints and tradeoffs, imposed by the physiology of neuronal populations, on plausible representation schemes. Using in vitro networks of rat cortical neurons as a model system, we compared the efficacy of different kinds of "neural codes" to represent both spatial and temporal input features. Two rate-based representation schemes and two time-based representation schemes were considered. Our results indicate that, by large, all representation schemes perform well in the various discrimination tasks tested, indicating the inherent redundancy in neural population activity; Nevertheless, differences in representation efficacy are identified when unique aspects of input features are considered. We discuss these differences in the context of neural population dynamics.

Citations

Apr 18, 2012·The European Journal of Neuroscience·Ofri LevyShimon Marom
Jan 27, 2012·The European Journal of Neuroscience·Antonny CzarneckiJürg Streit
Apr 24, 2015·Studies in History and Philosophy of Biological and Biomedical Sciences·Sara Green
Apr 24, 2015·Studies in History and Philosophy of Biological and Biomedical Sciences·Erez Braun, Shimon Marom
Mar 11, 2015·Frontiers in Integrative Neuroscience·Mark R DraniasAntonius M J VanDongen
Nov 22, 2008·PLoS Computational Biology·Goded ShahafShimon Marom
Feb 1, 2012·PLoS Computational Biology·Ioannis VlachosArvind Kumar
Nov 7, 2015·PloS One·Franz HamiltonNathalia Peixoto
Sep 9, 2008·Journal of Neuroscience Methods·Jonathan EricksonJerome Pine
Aug 11, 2016·PLoS Computational Biology·Sreedhar S KumarUlrich Egert
Feb 1, 2017·Journal of Neural Engineering·H Isaac ChenDouglas H Smith
Mar 10, 2012·Journal of Neurophysiology·Avner Wallach, Shimon Marom
Jan 1, 2013·Journal of Neurophysiology·Oliver WeihbergerUlrich Egert
Feb 26, 2016·Journal of Neural Engineering·Daniele PoliPaolo Massobrio
Oct 3, 2018·PLoS Computational Biology·Sahar GelfmanStephen J Eglen
Feb 29, 2020·Biological cybernetics·Christoph BauermeisterJochen Braun

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