PMID: 7523893Oct 16, 1994Paper

Tradescantia micronucleus bioassay

Mutation Research
T H MaM F Salamone

Abstract

Four coded chemicals, azidoglycerol (AG), N-methyl-N-nitrosourea (MNU), sodium azide (NaN3), and maleic hydrazide (MH), were tested with the Tradescantia micronucleus (Trad-MCN) bioassay by five independent laboratories from five different countries. The purpose of this international collaborative study was to evaluate four plant bioassays, of which the Trad-MCN assay was one, for their sensitivity, efficiency and reliability. The study was carried out under the sponsorship of the International Programme on Chemical Safety. All laboratories adhered to a standard Trad-MCN protocol which suggested that three replicate tests be conducted with each chemical. The results reported by all laboratories, although not equal, showed good agreement among the laboratories. In fact, all five laboratories obtained positive results with MH and MNU, while four of the five laboratories achieved positive results with NaN3. AG was tested in only three laboratories. Two reported negative results, while one reported positive results but only at a single high dose. The data from this study suggest that under normal conditions, the Trad-MCN bioassay is an efficient and reliable short-term bioassay for clastogens. It is suitable for the rapid screening...Continue Reading

References

May 1, 1977·Journal of Toxicology and Environmental Health·T J Haley
Jan 1, 1978·Mutation Research·Z Swietlińska, J Zuk
Apr 1, 1985·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·T H MaT S Lee
Jan 1, 1983·Environmental Mutagenesis·T H MaJ L Bare
Nov 1, 1953·Stain Technology·A D CONGER, L M FAIRCHILD
Mar 10, 1951·Nature·C D DARLINGTON, J McLENH

❮ Previous
Next ❯

Citations

Jul 4, 2002·Environmental Science and Pollution Research International·A KlumppP Vergne
Apr 18, 2006·Environmental Monitoring and Assessment·Martina SolenskáMiroslav Misík
Oct 16, 1994·Mutation Research·T H MaM F Salamone
Jun 4, 2013·Ecotoxicology and Environmental Safety·Kelly Cristina Tagliari de BritoVera Maria Ferrão Vargas
Jun 3, 1999·Mutation Research·S MonarcaG Nardi
May 10, 2001·Mutation Research·W F Grant, E T Owens
Jun 29, 2002·Mutation Research·William F Grant, Elizabeth T Owens
Jun 19, 1998·Mutation Research·W F Grant, E T Owens
Dec 18, 2010·Mutagenesis·M MisíkS Knasmueller
May 18, 2011·Environmental Health : a Global Access Science Source·Herbert A SisenandoSandra S Hacon
Nov 28, 2013·Environmental Science and Pollution Research International·Boscolli Barbosa PereiraSandra Morelli
Jan 29, 2016·Journal of Toxicology and Environmental Health. Part a·Carlos Fernando CamposBoscolli Barbosa Pereira
Nov 3, 2012·Ecotoxicology and Environmental Safety·Boscolli Barbosa PereiraSandra Morelli
Aug 2, 2011·Ecotoxicology and Environmental Safety·L F Andrade-VieiraH Azevedo
Jan 1, 2008·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Teresa Cristina dos Santos LealAdemir Xavier da Silva
Dec 2, 2015·Environmental Science and Pollution Research International·Miroslav MišíkMichael Kundi
Sep 4, 2015·Environmental Pollution·Caroline LanierAnnabelle Deram
Mar 25, 2016·Ecotoxicology and Environmental Safety·Prabhat Kumar Rai
Dec 2, 2004·Mutation Research·Paul A White, Larry D Claxton
Apr 30, 2013·Environmental Pollution·Hebe A CarrerasOmar Amador-Muñoz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.