Traditional and new approaches to the management of immune thrombocytopenia: issues of when and who to treat.

Hematology/oncology Clinics of North America
James B Bussel

Abstract

Diagnosis and management of chronic ITP requires experience and the appropriate use of the laboratory despite the absence of a diagnostic test for ITP. Consideration of secondary ITP is important because identification of immunodeficiency infections or of lymphoproliferative disorders would change the management approach to a given patient. The development of newer therapies such as rituximab and the thrombopoietic agents has had a major impact on the management of ITP. In the future, combinations of agents may be a critical approach although the schedule and dosing remains difficult to establish. Finally, current studies to augment therapy in newly diagnosed ITP patients to prevent chronic disease may lessen the number of patients in chronic disease category.

References

Feb 25, 1988·The New England Journal of Medicine·K B HymesS Karpatkin
Apr 29, 1993·The New England Journal of Medicine·M FigueroaR McMillan
May 5, 2001·The New England Journal of Medicine·R McMillan
Feb 5, 2003·Thrombosis Research·Yeon S AhnBrian Bowen
Aug 29, 2003·The New England Journal of Medicine·Yunfeng ChengGregory Cheng
Apr 23, 2004·Journal of Thrombosis and Haemostasis : JTH·K Onel, J B Bussel
Jun 9, 2005·Blood·Douglas B Cines, James B Bussel
Nov 2, 2006·Blood·Maria Gabriella MazzucconiUNKNOWN Gruppo Italiano Malattie EMatologiche dell'Adulto (GIMEMA) Thrombocytopenia Working Party
Aug 28, 2007·American Journal of Hematology·Robert McMillanJanet L Nichol
Mar 7, 2008·Journal of Clinical Immunology·C Cunningham-Rundles
Jun 25, 2008·British Journal of Haematology·Bethan Psaila, James B Bussel
Sep 5, 2009·American Journal of Hematology·Aisha HasanJames Bussel
Sep 8, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kristen M MarksMarshall J Glesby
Dec 17, 2009·Hematology·James N George, Richard H Aster

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Citations

Nov 26, 2010·Cell Biochemistry and Biophysics·Hui FanYang Liu
Aug 16, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Leonardo BoiocchiJulia Turbiner Geyer
Apr 10, 2013·Arthritis Research & Therapy·Stephan BlümlRonald Herbst

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