Traditional Chinese Medicine formula FTZ protects against polycystic ovary syndrome through modulating adiponectin-mediated fat-ovary crosstalk in mice.

Journal of Ethnopharmacology
Ying XuJiao Guo

Abstract

FuFang ZhenZhu TiaoZhi (FTZ) is a hospitalized traditional Chinese medicine herbal formula with documented metabolic benefits. Polycystic ovary syndrome (PCOS) characterized by ovarian dysfunction and insulin resistance represents one of the most common endocrine disorders in close association with metabolic dysfunction in premenopausal women. The present study aimed to investigate the preventive effect of FTZ on letrozole-induced experimental PCOS and its associated insulin resistance in mice. Prepubertal female mice in the experimental groups (letrozole and FTZ) received continuous infusion of letrozole (50 μg/day) for 35 days. FTZ was administrated to mice by oral gavage daily at dosage of 2.892 g/kg body weight for 5 weeks. All groups of mice were fed a high-fat diet (HFD). Ovary and adipose tissue were collected from all mice after 5 weeks and adiponectin, testosterone, estradiol, and luteinizing hormone level determined. Letrozole-induced morphological changes in the ovary, including a decreased number of corpora lutea and antral follicles, and increased cystic follicles, were significantly attenuated in FTZ-treated mice. Additionally, FTZ treatment notably reversed PCOS-related disruption of estrous status. PCOS-related ...Continue Reading

References

May 10, 2001·The Journal of Clinical Endocrinology and Metabolism·C WeyerP A Tataranni
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Robbie Y K ChanMan-Sau Wong
Mar 28, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A MeseguerA Cabero
Dec 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Weimin HeRonald M Evans
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Erin E Kershaw, Jeffrey S Flier
Aug 19, 2007·Trends in Endocrinology and Metabolism : TEM·Evanthia Diamanti-KandarakisGeorge P Chrousos
Aug 19, 2007·Trends in Endocrinology and Metabolism : TEM·Héctor F Escobar-Morreale, José L San Millán
Apr 27, 2010·Diabetes, Obesity & Metabolism·Stergios A PolyzosEleni Tsiaousi
Jan 26, 2011·Nature Reviews. Endocrinology·Mark O GoodarziRicardo Azziz
Sep 29, 2012·Vitamins and Hormones·Marie-France PalinBruce D Murphy
Oct 16, 2012·Endocrine Reviews·Evanthia Diamanti-Kandarakis, Andrea Dunaif
Aug 21, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G A Christou, D N Kiortsis
Feb 8, 2014·Journal of Ovarian Research·Saira Saeed MirzaMasood Anwar Qureshi
Jan 17, 2015·Trends in Endocrinology and Metabolism : TEM·Lisa J MoranHelena J Teede
Aug 22, 2015·Journal of Endocrinological Investigation·M C AmatoC Giordano
Apr 9, 2016·Journal of Basic and Clinical Pharmacy·Anroop B Nair, Shery Jacob
Jul 31, 2016·Journal of Endocrinological Investigation·K PolakB Meczekalski
Oct 21, 2016·British Journal of Pharmacology·Lavinia WoodwardCharalambos Antoniades
Apr 1, 2017·The American Journal of Chinese Medicine·Madeleine OngXianqin Qu
Aug 2, 2017·International Journal of Molecular Sciences·Timon E AdolphHerbert Tilg
Aug 10, 2017·Proceedings of the National Academy of Sciences of the United States of America·Anna BenrickIngrid Wernstedt Asterholm
Oct 13, 2017·Metabolism: Clinical and Experimental·Panagiotis AnagnostisRobert P Kauffman
Mar 24, 2018·Nature Reviews. Endocrinology·Héctor F Escobar-Morreale
Apr 22, 2018·The Journal of Steroid Biochemistry and Molecular Biology·Seema Patel
Jul 7, 2018·Comprehensive Physiology·Han Fang, Robert L Judd
Oct 6, 2018·Expert Opinion on Pharmacotherapy·Andrés E Ortiz-FloresHéctor F Escobar-Morreale
Dec 14, 2018·The Journal of Clinical Endocrinology and Metabolism·Solvejg L HansenBente Kiens

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