Traditional herbal formula Jakyakgamcho-tang (Paeonia lactiflora and Glycyrrhiza uralensis) impairs inflammatory chemokine production by inhibiting activation of STAT1 and NF-κB in HaCaT cells

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Soo-Jin JeongHyeun-Kyoo Shin

Abstract

A traditional herbal formula Jakyakgamcho-tang (JYGCT; Paeonia lactiflora and Glycyrrhiza uralensis) has been used for treatment of backache, muscle pain, acute abdominal pain, neuralgia, bronchial asthma, and painful peripheral neuropathy in Oriental medicine. We report on our experiments using the HaCaT human keratinocyte cell line showing that a traditional herbal formula JYGCT has inhibitory effects on inflammatory responses in skin. Stimulation with tumour necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) caused a significant increase in the production of the following chemokines: thymus- and activation-regulated chemokine (TARC)/CCL17; macrophage-derived chemokine (MDC)/CCL22; regulated on activation, normal T-cell expressed and secreted (RANTES)/CCL5; and interleukin-8 (IL-8) in HaCaT cells. By contrast, treatment with JYGCT extract significantly reduced the production of TARC, MDC, RANTES, and IL-8, but caused no cytotoxicity, compared with TNF-α and IFN-γ-treated control cells. Consistently, JYGCT extract downregulated the mRNA expression of TARC, MDC, RANTES, and IL-8 induced by TNF-α and IFN-γ in a dose-dependent manner. In addition, TNF-α and IFN-γ markedly increased the phosphorylation of signal transducer...Continue Reading

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Citations

Jan 12, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Sun Joo KimSangkyu Lee
Sep 22, 2016·Pharmaceutical Biology·Rui YangYing Liu
Jun 29, 2017·International Clinical Psychopharmacology·Siu W TangBrain E Leonard
Apr 9, 2020·Veterinary Sciences·Andrea MarchegianiMatteo Cerquetella
Sep 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Mingkwan Na TakuathungSeewaboon Sireeratawong
Dec 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ho-Sung LeeDae-Yeon Lee

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