Traditional risk factor assessment does not capture the extent of cardiovascular risk in systemic lupus erythematosus

Internal Medicine Journal
A B LeeA Jenkins

Abstract

Systemic lupus erythematosus (SLE) is associated with accelerated atherosclerosis. However, the degree of endothelial dysfunction and its relationship to traditional and novel cardiovascular risk factors have not been examined in SLE. In a case-control design, 35 patients with clinically stable SLE and 35 control subjects matched for age, sex, body mass index and smoking status were studied. Arterial elasticity, lipid profile, homocysteine, measures of inflammation and oxidative stress were determined. Among traditional vascular risk factors, there was a nonsignificant trend towards lower blood pressure in the control subjects, whereas low-density lipoprotein (LDL) cholesterol levels were significantly lower in the SLE group (2.5 vs 3.3 mmol/L, P < 0.001). Patients with SLE had significantly lower small artery elasticity (SAE; 4.9 vs 7.0 ml/mmHg x 100, P < 0.001) and higher plasma homocysteine (11.4 vs 8.3 mmol/L, P = 0.002) than control subjects. Levels of serum sVCAM-1 (614 vs 494 ng/mL, P = 0.002), oxidized LDL (144 vs 97, P < 0.001) and CD40 ligand (4385 vs 1373 pg/ml, P = 0.001) were significantly higher in SLE. Oxidized LDL levels, older age at SLE diagnosis and higher disease damage scores correlated inversely with SAE b...Continue Reading

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Citations

Sep 29, 2007·Annals of Human Genetics·Dharambir K SangheraM Ilyas Kamboh
Sep 24, 2010·Journal of Angiogenesis Research·Alicia J JenkinsJian-Xing Ma
Oct 12, 2010·Journal of Biomedicine & Biotechnology·Chary López-PedreraMaria José Cuadrado
Oct 13, 2012·Pharmacology & Therapeutics·Gianluca GrassiaPasquale Maffia
Oct 28, 2009·Clinical Biochemistry·Michael D W GriffinGeoffrey J Howlett
Jan 15, 2008·Autoimmunity Reviews·Jozélio Freire de CarvalhoEduardo Ferreira Borba
Oct 22, 2016·Mechanisms of Ageing and Development·Angelo FerranteGiovanni Triolo
Nov 17, 2015·The Journal of Rheumatology·Konstantinos TseliosMurray B Urowitz
Dec 8, 2017·Lupus Science & Medicine·Daniel BoulosAlberta Y Hoi
May 1, 2007·Arthritis and Rheumatism·Peter E WesterweelMarianne C Verhaar
Dec 5, 2009·Critical Reviews in Clinical Laboratory Sciences·Daniela GiustariniRanieri Rossi
Dec 26, 2016·Rheumatology·Diane Apostolopoulos, Eric F Morand

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