Traditional serrated adenoma has two distinct genetic pathways for molecular tumorigenesis with potential neoplastic progression.

Journal of Gastroenterology
Yoshihito TanakaTamotsu Sugai

Abstract

Recent studies have shown that traditional serrated adenoma (TSA) can be classified into BRAF and KRAS subtypes. Here, we examined the clinicopathological and molecular findings of 73 TSAs. TSAs were subclassified into BRAF type (46 cases, type A) and KRAS type (27 cases, type B) and divided into polyp head (TSA component) and base (precursor component [PC]) to identify pathological and molecular differences between the two components. BRAF and KRAS mutations, microsatellite instability (MSI), and DNA methylation status of the TSA component and PC were analyzed. In addition, immunohistochemical expressions of annexin A10, MUC2, MUC5AC, MUC6, and CD10 were also examined. Finally, we compared endoscopic findings with histological features. We classified type As into 31 type A1s with mutation of the corresponding PC (42.5%) and 15 type A2s without mutation of the PC (20.5%). None of the corresponding PCs without KRAS mutation were observed in type Bs. MSI was not detected in the TSAs examined. There were significant differences in the frequency of annexin A10 and MUC5AC expression between the three subtypes. Furthermore, we compared the TSA component with the corresponding PC to identify the progression mechanism between the two c...Continue Reading

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Methods Mentioned

BETA
PCR
Assay

Related Concepts

Adenoma
Hemophilia B
Classification
DNA
Endoscopy (Procedure)
Neprilysin
Neoplasms
Polyps
RNA Precursors
Posterior Cerebral Commissure

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