TRAF interactions with raft-like buoyant complexes, better than TRAF rates of degradation, differentiate signaling by CD40 and EBV latent membrane protein 1

International Journal of Cancer. Journal International Du Cancer
H Ardila-OsorioPierre Busson

Abstract

The CD40 receptor and the Epstein-Barr virus oncoprotein LMP1 are both members of the TNF-receptor family and share several signaling mediators, including TRAF2 and TRAF3. Depending on the cell lineage and stage of maturation, LMP1 and CD40 can have synergistic, antagonist or unrelated effects. Previous publications have suggested that both TRAF2 and TRAF3 move into lipid rafts upon LMP1 expression or CD40 activation, whereas their proteolysis is only enhanced by CD40. However CD40-induced proteolysis of TRAF2 has only been reported in murine cells, and there are conflicting data regarding translocation of TRAF2 into lipid rafts. We therefore investigated TRAF2 and TRAF3 modifications induced by CD40 and LMP1 signaling in a panel of human cell lines of lymphoid and epithelial origins. Upon CD40 stimulation, a marked redistribution of TRAF2 into the buoyant raft fraction was observed in all cell lines and was often associated with a similar redistribution of TRAF3. In contrast, only TRAF3 was redistributed into the raft fraction upon LMP1 expression. Moreover parallel changes in subcellular distribution of TRAF2 and TRAF3 were recorded by electron microscopy. A significant decrease in TRAF2 and TRAF3 concentrations triggered by ...Continue Reading

References

Sep 1, 1985·Journal of Virology·K P MannD A Thorley-Lawson
Nov 1, 1995·The Journal of Experimental Medicine·P GarroneJ Banchereau
May 4, 1999·International Journal of Cancer. Journal International Du Cancer·H Ardila-OsorioP Busson
Oct 19, 1999·Molecular and Cellular Biology·E J SmartM P Lisanti
Jan 27, 2000·Journal of Leukocyte Biology·C van Kooten, J Banchereau
Apr 20, 2000·The Journal of Biological Chemistry·D A Brown, E London
Jul 6, 2000·The EMBO Journal·P O VidalainS Manié
Oct 24, 2001·Seminars in Cancer Biology·A G Eliopoulos, L S Young
Mar 23, 2002·The Journal of Biological Chemistry·Kevin D BrownGail A Bishop
Jul 20, 2002·Trends in Neurosciences·Brian A Tsui-PierchalaEugene M Johnson
Oct 29, 2002·Cellular Signalling·Ngan Lam, Bill Sugden
Nov 27, 2002·Seminars in Cancer Biology·Nancy Raab-Traub
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bing HeAndrea Cerutti
Nov 19, 2003·Cell·Sean Munro
Dec 10, 2003·The Biochemical Journal·Linda J Pike
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Micah LuftigElliott Kieff

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Citations

Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·David G MeckesNancy Raab-Traub
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·David G MeckesNancy Raab-Traub
Feb 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Julia HauerHartmut Engelmann
May 14, 2011·European Journal of Immunology·Amal NadiriWalid Mourad
Feb 6, 2007·Cellular Signalling·Alexandre ArcaroMichael J Seckl
Jun 27, 2017·Nature Reviews. Microbiology·Nancy Raab-Traub, Dirk P Dittmer
May 28, 2020·Viruses·Flavia GiannessiElisabetta Affabris

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