TRAF-mediated TNFR-family signaling

Current Protocols in Immunology
Joseph R ArronYongwon Choi

Abstract

The tumor necrosis factor (TNF) superfamily consists of a wide variety of proteins, some cell-bound and others secreted, that regulate many cellular processes. In particular, TNF-family proteins regulate the life and death not only of tumor cells, but of activated cells of the immune system. This overview discusses the six known mammalian TRAF proteins, of which TRAF1, 2, 3, 5, and 6 have been shown to interact directly or indirectly with members of the TNFR superfamily. Structural features of TRAF proteins are described along with a discussion of TRAF-interacting proteins and the signaling pathways activated by TRAF proteins. Finally, a discussion is provided on the phenotypes of TRAF-knockout mice.

References

Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M BrockhausH Loetscher
Nov 21, 1986·Cell·D JohnsonM Chao
Mar 10, 1995·Science·G ChengD Baltimore
Jul 14, 1995·The Journal of Biological Chemistry·G E CrostonD V Goeddel
Apr 15, 1996·Genes & Development·G Cheng, D Baltimore
Jun 21, 1996·The Journal of Biological Chemistry·H NakanoK Okumura
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·H Y SongD V Goeddel
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·M RotheD V Goeddel
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·T K IshidaJ Inoue
Oct 3, 1996·Nature·Z CaoD V Goeddel
Apr 1, 1997·Current Opinion in Cell Biology·M KarinE Zandi
Apr 4, 1997·Science·G PanV M Dixit
Feb 21, 1998·Current Biology : CB·S A MarstersA Ashkenazi

❮ Previous
Next ❯

Citations

Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·J P C da CunhaS J de Souza
Mar 24, 2009·Annual Review of Immunology·Peter K Gregersen, Lina M Olsson
Nov 26, 2008·World Journal of Surgery·Min LiChangyi Chen
Oct 2, 2014·International Journal of Molecular Medicine·Weitao YaoPeng Zhang
Nov 16, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura M SnellTania H Watts
Apr 19, 2021·International Journal of Biological Macromolecules·Na LiZunnan Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.