TRAF-mediated TNFR-family signaling

Current Protocols in Immunology
Hyunil HaYongwon Choi

Abstract

The tumor necrosis factor (TNF) superfamily consists of a wide variety of cell-bound and secreted proteins that regulate numerous cellular processes. In particular, TNF-family proteins regulate the proliferation and death of tumor cells, as well as activated immune cells. This overview discusses the mammalian TNF receptor-associated factors (TRAFs), of which TRAF1, 2, 3, 5, and 6 have been shown to interact directly or indirectly with members of the TNF receptor superfamily. Structural features of TRAF proteins are described along with a discussion of TRAF-interacting proteins and the signaling pathways activated by the TRAF proteins. Finally, we examine the phenotypes observed in TRAF-knockout mice.

References

Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M BrockhausH Loetscher
Nov 21, 1986·Cell·D JohnsonM Chao
Mar 10, 1995·Science·G ChengD Baltimore
Jul 14, 1995·The Journal of Biological Chemistry·G E CrostonD V Goeddel
Apr 15, 1996·Genes & Development·G Cheng, D Baltimore
Jun 21, 1996·The Journal of Biological Chemistry·H NakanoK Okumura
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·H Y SongD V Goeddel
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·M RotheD V Goeddel
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·T K IshidaJ Inoue
Oct 3, 1996·Nature·Z CaoD V Goeddel
Apr 1, 1997·Current Opinion in Cell Biology·M KarinE Zandi
Apr 4, 1997·Science·G PanV M Dixit
Jul 10, 1997·Nature·M IrmlerJ Tschopp
Feb 21, 1998·Current Biology : CB·S A MarstersA Ashkenazi

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Citations

Aug 19, 2011·Genome Biology·Thomas SandmannKerstin Bartscherer
Aug 15, 2014·Frontiers in Genetics·Beichu Guo, Zihai Li
Mar 1, 2017·ELife·Gisela SchimmackDaniel Krappmann
Nov 13, 2010·Folia Histochemica Et Cytobiologica·Andrzej PlewkaKarolina Sieroń-Stołtny
Jun 11, 2011·Nature Reviews. Immunology·Hans HäckerMichael Karin
Oct 25, 2011·Immunological Reviews·Laura M SnellTania H Watts
Aug 21, 2013·Immunological Reviews·Michael E WortzmanTania H Watts
Sep 13, 2017·Interdisciplinary Sciences, Computational Life Sciences·Ria Biswas, Angshuman Bagchi
Dec 18, 2013·Hämostaseologie·D WolfA Zirlik
Oct 2, 2014·International Journal of Molecular Medicine·Weitao YaoPeng Zhang
Jan 1, 2014·The Journal of Experimental Medicine·Jae-Hoon ChangShao-Cong Sun
Oct 25, 2011·Immunological Reviews·Bärbel Schröfelbauer, Alexander Hoffmann
Jun 20, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gema Pérez-ChacónJuan M Zapata
Jan 19, 2016·Protein Science : a Publication of the Protein Society·Glenna Wink Foight, Amy E Keating
Nov 4, 2016·Journal of Cellular Physiology·Tiziana ZottiRomania Stilo
Oct 2, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shanshan LaiCheng Deng
May 23, 2012·Journal of Molecular Cell Biology·Xiao HeHong-Bing Shu
May 10, 2018·Nature Reviews. Gastroenterology & Hepatology·Susanne SchusterAriel E Feldstein
Nov 23, 2011·Journal of Cellular Physiology·Tiziana ZottiRomania Stilo
Nov 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claire M Buchta, Gail A Bishop
Jun 16, 2015·The Tohoku Journal of Experimental Medicine·Takanori SoNaoto Ishii
Feb 25, 2017·Journal of Experimental & Clinical Cancer Research : CR·Yonghao QiLijun Zhou
Apr 15, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroyuki NagashimaTakanori So
Dec 8, 2017·Scientific Reports·Rui ZhangZhenyu Li
Aug 24, 2019·The International Journal of Biochemistry & Cell Biology·Nasreena SajjadEijaz Ahmed Bhat
Jun 10, 2014·Seminars in Immunology·Achire N Mbanwi, Tania H Watts

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