Traffic-related air pollution and alveolar nitric oxide in southern California children

The European Respiratory Journal
Sandrah P EckelFrank D Gilliland

Abstract

Mechanisms for the adverse respiratory effects of traffic-related air pollution (TRAP) have yet to be established. We evaluated the acute effects of TRAP exposure on proximal and distal airway inflammation by relating indoor nitric oxide (NO), a marker of TRAP exposure in the indoor microenvironment, to airway and alveolar sources of exhaled nitric oxide (FeNO).FeNO was collected online at four flow rates in 1635 schoolchildren (aged 12-15 years) in southern California (USA) breathing NO-free air. Indoor NO was sampled hourly and linearly interpolated to the time of the FeNO test. Estimated parameters quantifying airway wall diffusivity (DawNO) and flux (J'awNO) and alveolar concentration (CANO) sources of FeNO were related to exposure using linear regression to adjust for potential confounders.We found that TRAP exposure indoors was associated with elevated alveolar NO. A 10 ppb higher indoor NO concentration at the time of the FeNO test was associated with 0.10 ppb higher average CANO (95% CI 0.04-0.16) (equivalent to a 7.1% increase from the mean), 4.0% higher J'awNO (95% CI -2.8-11.3) and 0.2% lower DawNO (95% CI -4.8-4.6).These findings are consistent with an airway response to TRAP exposure that was most marked in the dis...Continue Reading

References

Jan 15, 1994·Lancet·S A KharitonovP J Barnes
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·P E SilkoffN Zamel
Aug 4, 1998·Journal of Applied Physiology·N M Tsoukias, S C George
Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·G L PiacentiniA L Boner
Mar 5, 1999·The European Respiratory Journal·P A SteerenbergJ G van Amsterdam
Nov 23, 2000·Indoor Air·C J Weschler
Jun 19, 2001·The European Respiratory Journal·P PenttinenJ Pekkanen
Aug 8, 2001·The European Respiratory Journal·Q JöbsisJ C de Jongste
Feb 10, 2004·Journal of Applied Physiology·Steven C GeorgePhilip E Silkoff
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
May 6, 2006·Environmental Health Perspectives·Rob McConnellJohn Peters
Oct 23, 2008·Journal of Exposure Science & Environmental Epidemiology·William S LinnFrank D Gilliland
Jul 25, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ulrike GehringJohan C De Jongste
Sep 24, 2009·Pediatric Pulmonology·William S LinnFrank D Gilliland
Oct 30, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Hsu-Chung LiuMing-Chih Chou
Jun 28, 2011·American Journal of Respiratory and Critical Care Medicine·Talat IslamRob McConnell
Jun 29, 2011·Environmental Health Perspectives·Sandrah P EckelFrank D Gilliland
Dec 14, 2011·Journal of Allergy·Stefania La GruttaGiovanni Viegi
Sep 1, 1986·Environmental Science & Technology·W W Nazaroff, G R Cass
May 3, 2012·Journal of Breath Research·Caterina BuccaGiovanni Rolla
Mar 1, 2013·Journal of Breath Research·S M CristescuM Högman
May 7, 2013·Occupational and Environmental Medicine·Nadine S M OffermansPiet A van den Brandt
May 16, 2013·Journal of Exposure Science & Environmental Epidemiology·Ralph J DelfinoMartin M Shafer
May 21, 2013·Pediatric Pulmonology·William S LinnFrank D Gilliland
Nov 12, 2013·Epidemiology·Lars ModigAnna-Carin Olin
Jan 28, 2014·PloS One·Sandrah P EckelFrank D Gilliland
Apr 4, 2014·Occupational and Environmental Medicine·Kiros BerhaneFrank D Gilliland
May 6, 2014·Lancet·Michael Guarnieri, John R Balmes
Jul 22, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M C ScarpaP Maestrelli
May 1, 2009·Atmospheric Environment·Shishan HuArthur M Winer
Dec 6, 2014·Occupational and Environmental Medicine·Nadine Janet KubeschMark J Nieuwenhuijsen

❮ Previous
Next ❯

Citations

May 2, 2016·The European Respiratory Journal·Isabella Annesi-Maesano, Anh Tuan Dinh-Xuan
Jun 27, 2019·Journal of Breath Research·Tuomas Karvonen, Lauri Lehtimäki
Aug 3, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Seerooven CurpenReshma D Ramracheya
Sep 25, 2019·Journal of Breath Research·Tuomas Karvonen, Lauri Lehtimäki
Apr 9, 2019·Annals of the American Thoracic Society·Stephanie Lovinsky-DesirKyung Hwa Jung
Mar 27, 2020·BMJ Open Respiratory Research·Michael J AbramsonTamara Schikowski
Jun 23, 2018·The Science of the Total Environment·Jing ShangYuanxun Zhang
Jun 22, 2021·Journal of Environmental Health Science & Engineering·M ShehabJ M Delgado-Saborit
Aug 27, 2021·Scientific Reports·Jingying WengSandrah P Eckel
Sep 9, 2021·Environmental Health Perspectives·Kyung Hwa JungStephanie Lovinsky-Desir
Sep 15, 2021·Angewandte Chemie·Longcheng ZhangXuping Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.