Trafficking and signaling pathways of nuclear localizing protein ligands and their receptors

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Howard M JohnsonD A Jans

Abstract

Interaction of ligands such as epidermal growth factor and interferon-gamma with the extracellular domains of their plasma membrane receptors results in internalization followed by translocation into the nucleus of the ligand and/or receptor. There has been reluctance, however, to ascribe signaling importance to this, the focus instead being on second messenger pathways, including mobilization of kinases and inducible transcription factors (TFs). The latter, however, fails to explain the fact that so many ligands stimulate the same second messenger cascades/TFs, and yet show distinct gene activation profiles. This is particularly apt in the case of the seven STAT TFs that are held to be the mediators of the distinct cellular functions of over 60 ligands. The current review focuses on five representative nuclear localizing ligands for which there is documentation of translocation into the cytosol and nucleus through well-characterized pathways, in addition to a role in gene activation by ligand/receptor in the nucleus.

References

Jan 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U MartiA L Jones
Dec 1, 1990·Endocrinology·C V ClevengerM B Prystowsky
Feb 1, 1989·Archives of Biochemistry and Biophysics·E M Rakowicz-SzulczynskaH Koprowski
Jul 16, 1986·Biochemical and Biophysical Research Communications·H S MacDonaldS E Grossberg
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E M Rakowicz-SzulczynskaH Koprowski
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G BoucheF Amalric
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·T Bader, J Weitzerbin
Dec 22, 1995·The Journal of Biological Chemistry·A WiedłochaS Olsnes
Mar 1, 1996·Neuroendocrinology·H C MertaniG Morel
Dec 6, 1996·The Journal of Biological Chemistry·T SekimotoY Yoneda
Dec 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G MuthukumaranS Pestka
Jul 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D A Jans, G Hassan
Dec 29, 1998·The Journal of Biological Chemistry·P S SubramaniamH M Johnson
Jun 8, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D A JansM H Lam
Jul 11, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J LarkinP S Subramaniam
Aug 10, 2000·Molecular Endocrinology·M A RycyzynC V Clevenger
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·A BegittU Vinkemeier
Jan 11, 2001·The Journal of Biological Chemistry·K MelenI Julkunen
Jul 13, 2001·The Journal of Biological Chemistry·B CatimelB Kobe
Aug 10, 2001·Cellular Signalling·T ZhuP E Lobie
Dec 19, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·P S SubramaniamH M Johnson
Feb 2, 2002·Science·Ali H Brivanlou, James E Darnell
Feb 9, 2002·Nature Cell Biology·M OksvoldI Madshus
May 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael A Rycyzyn, Charles V Clevenger
Jun 6, 2002·The Journal of Biological Chemistry·Riku FagerlundIlkka Julkunen
Jul 10, 2002·Trends in Immunology·Michael I Bukrinsky

❮ Previous
Next ❯

Citations

Sep 14, 2007·Histochemistry and Cell Biology·Liyong ChenNing Guo
May 3, 2005·Cytokine & Growth Factor Reviews·Lisa DaileyClaudio Basilico
Mar 10, 2010·Antioxidants & Redox Signaling·Young-Mi Go, Dean P Jones
Oct 5, 2012·Molecular Biology of the Cell·Kazuhisa KoizumiTakeshi Endo
Mar 2, 2011·American Journal of Clinical Oncology·Ana Paula AraújoRui Medeiros
Jan 26, 2011·Molecular and Cellular Biology·Michèle SabbahGérard Redeuilh
Jun 24, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Francis W FlynnZhaojie Zhang
Jul 23, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Menghong SunIgnacio I Wistuba
Jun 20, 2013·The Journal of Clinical Investigation·Yuyan ZhuAkira Nakagawara
Mar 17, 2010·BMC Cell Biology·Jenny E FelinLaura C Bridgewater
Feb 3, 2011·Annals of Surgical Oncology·Kenichiro YoshitakeShigeki Arii
Mar 4, 2005·Chemical & Pharmaceutical Bulletin·Tadahiro NishimuraSusumu Kitanaka
Jun 5, 2008·PloS One·Ayelet Di SegniRonit Pinkas-Kramarski
Aug 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Becky L Conway-CampbellMichael J Waters
Aug 12, 2006·Canadian Journal of Physiology and Pharmacology·Fernand GobeilDavid Barbaz
Jun 22, 2011·Biochemical and Biophysical Research Communications·Ezra N Noon-SongHoward M Johnson
Nov 3, 2009·Molecular and Cellular Endocrinology·Oliver H Krämer, Thorsten Heinzel
Oct 28, 2008·Experimental Cell Research·Graham Carpenter, Hong-Jun Liao
Sep 25, 2007·The International Journal of Biochemistry & Cell Biology·Andrew J BrooksMichael J Waters
Jun 23, 2007·European Journal of Cell Biology·Iwona PileckaMarta Miaczynska
May 12, 2007·Biochimie·Julie ClaudinonChristophe Lamaze
Jan 30, 2007·Acta histochemica·Eric J Arnoys, John L Wang
Apr 20, 2005·Journal of Cellular Biochemistry·John J Krolewski
Apr 20, 2007·Developmental Neurobiology·Dongguang WeiMats Ulfendahl
Dec 15, 2005·The Journal of Pathology·Denis KhnykinJan Delabie
Mar 29, 2012·The Biochemical Journal·Howard M JohnsonChulbul M Ahmed
Sep 21, 2011·Seminars in Cell & Developmental Biology·Ian G Mills

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.