Trafficking of high avidity HER-2/neu-specific T cells into HER-2/neu-expressing tumors after depletion of effector/memory-like regulatory T cells.

PloS One
Vivian L WeissTodd D Armstrong

Abstract

Cancer vaccines are designed to activate and enhance cancer-antigen-targeted T cells that are suppressed through multiple mechanisms of immune tolerance in cancer-bearing hosts. T regulatory cell (Treg) suppression of tumor-specific T cells is one barrier to effective immunization. A second mechanism is the deletion of high avidity tumor-specific T cells, which leaves a less effective low avidity tumor specific T cell repertoire available for activation by vaccines. Treg depleting agents including low dose cyclophosphamide (Cy) and antibodies that deplete CD25-expressing Tregs have been used with limited success to enhance the potency of tumor-specific vaccines. In addition, few studies have evaluated mechanisms that activate low avidity cancer antigen-specific T cells. Therefore, we developed high and low avidity HER-2/neu-specific TCR transgenic mouse colonies specific for the same HER-2/neu epitope to define the tolerance mechanisms that specifically affect high versus low avidity tumor-specific T cells. High and low avidity CD8(+) T cell receptor (TCR) transgenic mice specific for the breast cancer antigen HER-2/neu (neu) were developed to provide a purified source of naïve, tumor-specific T cells that can be used to study ...Continue Reading

References

Apr 1, 1995·Current Opinion in Immunology·J Sprent, S R Webb
Mar 27, 1995·Journal of Immunological Methods·V KouskoffD Mathis
Jan 1, 1997·Advances in Cancer Research·M L Disis, M A Cheever
Jan 1, 1997·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·M A Alaoui-JamaliL Yen
Oct 12, 2000·Nihon rinsho. Japanese journal of clinical medicine·Y Takatsuka
Oct 31, 2000·International Journal of Cancer. Journal International Du Cancer·M G DiodoroP Musiani
Feb 13, 2001·Immunity·M Correia-NevesC Benoist
Feb 22, 2002·Medicinal Research Reviews·Helena Yusuf-MakagiansarTeruna J Siahaan
Feb 4, 2003·Nature Immunology·E John WherryRafi Ahmed
Mar 4, 2003·Nature Immunology·Roli KhattriFred Ramsdell
Mar 5, 2003·Annual Review of Immunology·Drew Pardoll
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne M ErcoliniElizabeth M Jaffee
Aug 20, 2003·The Journal of Experimental Medicine·Willem W OverwijkNicholas P Restifo
Nov 6, 2003·Journal of Cell Science·Nancy HoggAlison McDowall
May 4, 2004·Nature Reviews. Cancer·Eli Gilboa
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annemieke Th den BoerRené E M Toes
Sep 24, 2004·The Journal of Experimental Medicine·Mary Jo TurkAlan N Houghton
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael A LymanLinda A Sherman
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul A AntonyNicholas P Restifo
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Santiago ZelenayJocelyne Demengeot
May 11, 2005·The Journal of Experimental Medicine·Anne M ErcoliniElizabeth M Jaffee
Jul 19, 2005·Nature Immunology·Amanda L MarzoLeo Lefrançois
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Satoshi MurataR Todd Reilly
Apr 20, 2006·Nature Reviews. Immunology·Luca GattinoniNicholas P Restifo
Jul 11, 2006·Immunological Reviews·Christopher A KlebanoffNicholas P Restifo
Aug 15, 2006·Immunological Reviews·Ethan M ShevachAngela M Thornton
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Nevil J Singh, Ronald H Schwartz
Sep 16, 2006·Immunological Reviews·Thomas F GajewskiHelena Harlin
Dec 16, 2006·International Reviews of Immunology·Kristen M HegeDrew Pardoll
May 4, 2007·The Journal of Clinical Investigation·Carl H June
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elizabeth A ManningLeisha A Emens
Jul 10, 2007·Biochemical and Biophysical Research Communications·Meiqing ShiJim Xiang
Jul 27, 2007·Seminars in Cancer Biology·Rachel H McMahan, Jill E Slansky
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura StraussTheresa L Whiteside
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·S B Justin WongLinda A Sherman

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Citations

Apr 30, 2014·Cancer Immunology, Immunotherapy : CII·Zaima Mazorra Herrera, Tania Crombet Ramos
Dec 21, 2013·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Arthur A HurwitzZiqiang Zhu
Jan 24, 2013·Breast Cancer Research and Treatment·Ursula WiedermannChristoph C Zielinski
Sep 17, 2013·Trends in Molecular Medicine·Barbara Seliger, Rolf Kiessling
Dec 5, 2015·Frontiers in Immunology·Michael HebeisenNathalie Rufer
May 16, 2014·Clinical and Experimental Immunology·C Oelkrug, J M Ramage
Oct 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Jing-Lan HuLan-Jie Yao
Jan 7, 2014·Journal of Zhejiang University. Science. B·Xinguo Jiang
Nov 22, 2012·Oncoimmunology·Vivian L WeissTodd D Armstrong
Jun 25, 2013·Molecular and Cellular Endocrinology·Xinguo Jiang, David J Shapiro
May 10, 2020·Molecular Carcinogenesis·Michele M Hoffmann, Jill E Slansky
Dec 4, 2016·Cancer Metastasis Reviews·Alison Spellman, Shou-Ching Tang
Oct 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sourabh ShuklaNicole F Steinmetz
Feb 8, 2019·Cancer Immunology Research·Lukas W PfannenstielBrian R Gastman
Oct 4, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paola FilipazziLicia Rivoltini
Jan 19, 2021·Oncoimmunology·Zoila A Lopez-BujandaCharles G Drake

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
dissection
transgenic
flow cytometry
PCR
FACS

Software Mentioned

Pestle
Excel
Bond maX
Spice
Bond
max
Leica

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