PMID: 25743849Mar 7, 2015Paper

TRAIL and Bortezomib: killing cancer with two stones

Asian Pacific Journal of Cancer Prevention : APJCP
Muhammad Zahid QureshiAmmad Ahmad Farooqi

Abstract

Cancer genomics and proteomics have undergone considerable broadening in the past decades and increasingly it is being realized that solid/liquid phase microarrays and high-throughput resequencing have provided platforms to improve our existing knowledge of determinants of cancer development, progression and survival. Loss of apoptosis is a widely and deeply studied process and different approaches are being used to restore apoptosis in resistant cancer phenotype. Modulating the balance between pro-apoptotic and anti-apoptotic proteins is essential to induce apoptosis. It is becoming more understood that pharmacological inhibition of the proteasome might prove to be an effective option in improving TRAIL induced apoptosis in cancer cells. Keeping in view rapidly accumulating evidence of carcinogenesis, metastasis, resistance against wide ranging therapeutics and loss of apoptosis, better knowledge regarding tumor suppressors, oncogenes, pro-apoptotic and anti-apotptic proteins will be helpful in translating the findings from benchtop to bedside.

References

Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter F BrossRichard Pazdur
Apr 29, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas UnterkircherSimone Fulda
Nov 28, 2012·Apoptosis : an International Journal on Programmed Cell Death·Syam Prakash SomasekharanJean-Claude Martinou
Oct 8, 2014·Journal of Neuropathology and Experimental Neurology·Ronald KoschnyTom M Ganten

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Citations

Jan 5, 2018·The Journal of Clinical Endocrinology and Metabolism·Poyil PratheeshkumarKhawla S Al-Kuraya

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