TRAIL modulates the immune system and protects against the development of diabetes

Journal of Immunology Research
Fleur BossiBruno Fabris

Abstract

TRAIL or tumor necrosis factor (TNF) related apoptosis-inducing ligand is a member of the TNF superfamily of proteins, whose best characterized function is the induction of apoptosis in tumor, infected, or transformed cells through activation of specific receptors. In nontransformed cells, however, the actions of TRAIL are less well characterized. Recent studies suggest that TRAIL may be implicated in the development and progression of diabetes. Here we review TRAIL biological actions, its effects on the immune system, and how and to what extent it has been shown to protect against diabetes.

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Citations

Feb 26, 2016·Cellular and Molecular Life Sciences : CMLS·Veronica TisatoGiorgio Zauli
Oct 1, 2016·The International Journal of Biochemistry & Cell Biology·Rebecca VoltanVeronica Tisato
Jul 13, 2018·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Wei-Wei ChangYing-Shui Yao
Nov 24, 2017·Clinical Science·Stella BernardiBruno Fabris
Mar 5, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Valeriya Gyurkovska, Nina Ivanovska
Jun 21, 2017·International Journal of Hematology·Chunyan LiuZonghong Shao
May 18, 2019·Clinical Science·Stella BernardiVeronica Tisato
Apr 17, 2021·Drug Discovery Today·Maryam Mahjoubin-TehranAmirhossein Sahebkar
Oct 15, 2020·Journal of Neuroinflammation·Chiara BurgalettoGiuseppina Cantarella

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